Pbx 2 Antibody (SS-24): sc-81987
- Pbx 2 Antibody (SS-24) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against recombinant Pbx 2 of human origin
- recommended for detection of Pbx 2 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pbx 2 Antibody (SS-24). This work is in progress.
Pbx 2 Antibody (SS-24) is a mouse monoclonal IgG2a antibody that detects Pbx 2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pbx 2 is a crucial member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins, which play significant roles in regulating gene expression during development and differentiation. Notably, Pbx 2 is ubiquitously expressed across various fetal and adult tissues, highlighting its importance in maintaining cellular functions. Pbx 2 expression in lymphoid cells, where Pbx 1 is absent, suggests a unique role in immune system development and function. Pbx 2′s structure, characterized by a highly conserved homeobox domain, allows interaction with other transcription factors, thereby influencing the transcriptional regulation of target genes essential for cellular processes. Understanding Pbx 2 function and interactions is vital, as dysregulation has been implicated in various leukemias, including human pre-B cell acute leukemias, where chromosomal rearrangements can lead to the formation of fusion proteins that disrupt normal cellular functions. Anti-Pbx 2 antibody (SS-24) is an invaluable tool for researchers investigating Pbx 2′s role in health and disease.
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Pbx 2 Antibody (SS-24) References:
- Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. | Longobardi, E. and Blasi, F. 2003. J Biol Chem. 278: 39235-41. PMID: 12871956
- The TALE homeodomain protein Pbx2 is not essential for development and long-term survival. | Selleri, L., et al. 2004. Mol Cell Biol. 24: 5324-31. PMID: 15169896
- Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. | Capellini, TD., et al. 2006. Development. 133: 2263-73. PMID: 16672333
- PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. | Monica, K., et al. 1991. Mol Cell Biol. 11: 6149-57. PMID: 1682799
- Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. | Capellini, TD., et al. 2008. Dev Biol. 321: 500-14. PMID: 18691704
- [Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer]. | Jin, SQ., et al. 2014. Zhejiang Da Xue Xue Bao Yi Xue Ban. 43: 413-9. PMID: 25187455
- Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer. | Lin, J., et al. 2021. Aging (Albany NY). 13: 6606-6624. PMID: 33535170
- PBX2-Mediated circTLK1 Activates JAK/STAT Signaling to Promote Gliomagenesis via miR-452-5p/SSR1 Axis. | Li, J., et al. 2021. Front Genet. 12: 698831. PMID: 34721518
- Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1. | Wada, R., et al. 2023. J Biochem. 173: 129-138. PMID: 36477205
- The E2F1-HOXB9/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer. | Zhang, J., et al. 2023. J Pathol. 260: 402-416. PMID: 37272544
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pbx 2 Antibody (SS-24) | sc-81987 | 50 µg/0.5 ml | $322.00 |