ErbB2/HER2 Antibody (42): sc-136294
- ErbB2/HER2 Antibody (42) is a mouse monoclonal IgG2b provided at 50 µg/0.5 ml
- raised against amino acids 182-373 of Neu of rat origin
- recommended for detection of Neu of mouse, rat and human origin by WB, IP and IF
- See ErbB2/HER2 (3B5): sc-33684 for ErbB2/HER2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ErbB2/HER2 Antibody (42). This work is in progress.
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SEE ALSO...
Neu Antibody (42) is a mouse monoclonal IgG2b antibody that detects Neu in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Neu, a member of the EGF receptor family, plays a crucial role in cell signaling and is known for involvement in various cellular processes, including cell proliferation, differentiation, and survival. Neu (42) antibody targets a protein primarily located on the cell membrane, where Neu functions as a receptor tyrosine kinase. This localization allows Neu to interact with extracellular ligands, leading to activation of downstream signaling pathways that influence tumorigenesis and metastasis. Notably, Neu heterodimerizes with other EGF receptor family members, such as ErbB-3, which enhances signaling capabilities and contributes to aggressive behavior of certain cancers, particularly breast carcinoma, where Neu amplification or overexpression is observed in 20-30% of cases. Anti-Neu antibody (42) can accurately measure Neu expression levels, providing valuable insights into disease prognosis and therapeutic targeting, making this antibody an essential tool for researchers studying cancer biology and treatment strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ErbB2/HER2 Antibody (42) References:
- Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumors. | Landis, MD., et al. 2006. Oncogene. 25: 3325-34. PMID: 16434967
- Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer. | Mosley, JD., et al. 2007. Mol Cancer Ther. 6: 2188-97. PMID: 17699716
- Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers. | Tomizawa, K., et al. 2011. Lung Cancer. 74: 139-44. PMID: 21353324
- When tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene. | Chow, A., et al. 2011. J Mammary Gland Biol Neoplasia. 16: 81-8. PMID: 21590373
- The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance. | Whelan, KA., et al. 2013. J Biol Chem. 288: 15865-77. PMID: 23585570
- MiR-34a modulates ErbB2 in breast cancer. | Wang, Y., et al. 2017. Cell Biol Int. 41: 93-101. PMID: 27813227
- Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells. | Chen, Y., et al. 2021. Cancers (Basel). 13: PMID: 33801244
- Comparison of Management and Outcomes in ERBB2-Low vs ERBB2-Zero Metastatic Breast Cancer in France. | de Calbiac, O., et al. 2022. JAMA Netw Open. 5: e2231170. PMID: 36107428
- ErbB2-NOTCH1 axis controls autophagy in cardiac cells. | Fortini, F., et al. 2024. Biofactors.. PMID: 38994725
- Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival. | Saffari, B., et al. 1995. Cancer Res. 55: 5693-8. PMID: 7585656
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ErbB2/HER2 Antibody (42) | sc-136294 | 50 µg/0.5 ml | $322.00 |