Mucin 5AC/MUC5AC Antibody (2X123): sc-71620
- Mucin 5AC/MUC5AC Antibody (2X123) is a mouse monoclonal IgG1, cited in 6 publications, provided at 200 µg/ml
- raised against M1 Mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le (a-b) patient
- recommended for detection of Mucin 5AC of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and rabbit, porcine, feline, avian, monkey and hedgehog
- See Mucin 5AC/MUC5AC (45M1): sc-21701 for Mucin 5AC/MUC5AC antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 5AC/MUC5AC Antibody (2X123). This work is in progress.
Mucin 5AC Antibody (2X123) is a mouse monoclonal IgG1 antibody that detects Mucin 5AC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Mucin 5AC is a gel-forming mucin primarily secreted by surface mucous cells, playing a crucial role in the protection and lubrication of epithelial surfaces. Anti-Mucin 5AC antibody (2X123) recognizes a protein structure characterized by high molecular weight and complex O-linked carbohydrates, essential for forming protective mucus barriers that maintain mucosal surface integrity in respiratory and gastrointestinal tracts. Mucin 5AC synthesis is regulated by glucocorticoids necessary for mRNA expression, and pro-inflammatory cytokines like interleukin-6 and tumor necrosis factor-alpha enhance secretion during chronic inflammation. Mucin 5AC expression is influenced by retinoic acid and thyroid hormones, highlighting importance in both normal physiological processes and pathological conditions. Mucin 5AC monoclonal antibody (2X123) enables research in various tissues, including endocervical epithelium and gastric cells, supporting studies in mucin biology and diseases such as asthma and chronic inflammatory conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mucin 5AC/MUC5AC Antibody (2X123) References:
- Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide. | Sueyoshi, S., et al. 2004. Int Arch Allergy Immunol. 134: 273-80. PMID: 15205558
- Effects of mycophenolate mofetil on proliferation and mucin-5AC expression in human conjunctival goblet cells in vitro. | He, H., et al. 2010. Mol Vis. 16: 1913-9. PMID: 21031014
- Identification of HLA-A*0201- and A*2402-restricted epitopes of mucin 5AC expressed in advanced pancreatic cancer. | Yamazoe, S., et al. 2011. Pancreas. 40: 896-904. PMID: 21697763
- Effects of ambient levels of traffic-derived air pollution on the ocular surface: analysis of symptoms, conjunctival goblet cell count and mucin 5AC gene expression. | Torricelli, AA., et al. 2014. Environ Res. 131: 59-63. PMID: 24657517
- Proteomic analysis of cancer and mesothelial cells reveals an increase in Mucin 5AC during ovarian cancer and peritoneal interaction. | Musrap, N., et al. 2014. J Proteomics. 103: 204-15. PMID: 24726482
- Interleukin (IL) 36 gamma induces mucin 5AC, oligomeric mucus/gel-forming expression via IL-36 receptor-extracellular signal regulated kinase 1 and 2, and p38-nuclear factor kappa-light-chain-enhancer of activated B cells in human airway epithelial cells. | Bae, CH., et al. 2018. Am J Rhinol Allergy. 32: 87-93. PMID: 29644902
- Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2. | Lin, XP., et al. 2018. Chin Med J (Engl). 131: 1686-1693. PMID: 29998888
- Tepotinib Inhibits the Epithelial-Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels. | Sohn, SH., et al. 2020. Int J Mol Sci. 21: PMID: 32825724
- Pepsin exposure in a non-acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor κB (NF-κB) in human airway epithelial cells. | Choi, YS., et al. 2021. Int Forum Allergy Rhinol. 11: 894-901. PMID: 32846027
- Knockdown of lncRNA ANRIL suppresses the production of inflammatory cytokines and mucin 5AC in nasal epithelial cells via the miR-15a-5p/JAK2 axis. | Liu, HW., et al. 2021. Mol Med Rep. 23: PMID: 33325534
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 5AC/MUC5AC Antibody (2X123) | sc-71620 | 200 µg/ml | $322.00 |