MDHC Antibody (28): sc-101516

MDHC Antibody (28) is a mouse monoclonal IgG1 antibody that detects malate dehydrogenase cytosolic (MDHC) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MDHC is a crucial NAD-dependent enzyme that plays a significant role in glycometabolism by catalyzing the conversion of L-malate and NAD into oxaloacetate and NADH, which is vital for energy production in aerobic conditions. Anti-MDHC antibody (28) targets an enzyme predominantly expressed in tissues such as the brain, heart, and skeletal muscle, where MDHC supports essential functions including muscle contraction, neuronal signal transmission, and various metabolic pathways. MDHC operates as a homodimer and is highly conserved across different species, including plants, animals, and bacteria, highlighting its fundamental biological importance. MDHC activity is regulated by hormones such as the sesquiterpenoid juvenile hormone and the steroid hormone ecdysone, which underscores MDHC′s role in developmental processes and metabolic regulation. With an ability to facilitate critical biochemical reactions, MDHC is integral to maintaining cellular energy homeostasis and overall physiological function, making anti-MDHC antibody (28) an invaluable tool for researchers studying metabolic pathways and energy production mechanisms.

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MDHC Antibody (28) References:

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2. Effect of mono- and diketone group in curcumin analogues on amyloid fibrillation of hen egg white lysozyme.  |  Gao, X., et al. 2023. Biophys Chem. 292: 106913. PMID: 36330890
3. Bacterial Extracellular Vesicles: A Candidate Molecule for the Diagnosis and Treatment of Allergic Diseases.  |  Choi, Y., et al. 2023. Allergy Asthma Immunol Res. 15: 279-289. PMID: 37188485
4. Production of L-Malic Acid by Metabolically Engineered Aspergillus nidulans Based on Efficient CRISPR-Cas9 and Cre-loxP Systems.  |  Chen, Z., et al. 2023. J Fungi (Basel). 9: PMID: 37504708
5. Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice.  |  Kwon, H., et al. 2023. Exp Mol Med. 55: 2067-2082. PMID: 37704750
6. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors.  |  Martinson, EA., et al. 1994. Cell Mol Biol (Noisy-le-grand). 40: 627-34. PMID: 7526916
7. Protein tyrosine phosphorylation in equine platelets: the effect of stimulation by thrombin and platelet-activating factor (PAF).  |  Dillon, AM. and Heath, MF. 1995. Equine Vet J. 27: 448-58. PMID: 8565942
8. Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.  |  Koch, JA., et al. 1996. Biochem Biophys Res Commun. 225: 531-6. PMID: 8753796
9. Attenuation of endothelin-1-induced calcium response by tyrosine kinase inhibitors in vascular smooth muscle cells.  |  Liu, CY. and Sturek, M. 1996. Am J Physiol. 270: C1825-33. PMID: 8764168
10. Is tyrosine kinase activation involved in basophil histamine release in asthma due to western red cedar?  |  Frew, A., et al. 1998. Allergy. 53: 139-43. PMID: 9534911

The preferred MDHC antibody is MDHC Antibody (H-6): sc-166879.