LEF-1 Antibody (REMB1): sc-56722
- LEF-1 Antibody (REMB1) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against full length LEF-1 of human origin
- recommended for detection of β-catenin binding domain of LEF-1 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with TCF1 or TCF4
- See LEF-1 (B-10): sc-374412 for LEF-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LEF-1 Antibody (REMB1). This work is in progress.
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LEF-1 Antibody (REMB1) is a mouse monoclonal IgG1 antibody that detects LEF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LEF-1, a member of the TCF/LEF family of transcription factors, plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. LEF-1 is primarily located in the nucleus, where LEF-1 interacts with β-catenin to regulate the transcription of Wnt target genes. Nuclear localization of LEF-1 allows for precise control of gene expression in response to Wnt signaling, influencing cell fate decisions during embryonic development and tissue homeostasis. Dysregulation of LEF-1 and associated pathways can lead to various diseases, including cancer, highlighting the importance of studying LEF-1 for understanding tumorigenesis and potential therapeutic interventions. Anti-LEF-1 antibody (REMB1) serves as an invaluable tool for researchers investigating the complexities of Wnt signaling and its implications in developmental biology and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LEF-1 Antibody (REMB1) References:
- LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. | Skokowa, J. and Welte, K. 2007. Ann N Y Acad Sci. 1106: 143-51. PMID: 17360796
- A comparative analysis of LEF-1 in odontogenic and salivary tumors. | Bilodeau, EA., et al. 2015. Hum Pathol. 46: 255-9. PMID: 25497834
- LEF-1: Diagnostic utility in distinguishing basaloid neoplasms of the salivary gland. | Schmitt, AC., et al. 2017. Diagn Cytopathol. 45: 1078-1083. PMID: 28972308
- Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction. | Elayyan, J., et al. 2022. Proc Natl Acad Sci U S A. 119: e2116855119. PMID: 35594394
- Immunohistochemical staining of LEF-1 is a useful marker for distinguishing WNT-activated medulloblastomas. | Wang, D., et al. 2022. Diagn Pathol. 17: 69. PMID: 36096860
- LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. | Ngai, H., et al. 2023. Cancer Immunol Res. 11: 171-183. PMID: 36484736
- LEF1 isoforms regulate cellular senescence and aging. | Jia, M., et al. 2023. Aging Cell. 22: e14024. PMID: 37961030
- A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency. | Ward, BJH., et al. 2023. PLoS Pathog. 19: e1011873. PMID: 38113273
- LEF-1 immunohistochemistry, a better diagnostic biomarker than β-catenin for medulloblastoma, WNT-activated subtyping. | Aboubakr, O., et al. 2024. J Neuropathol Exp Neurol. 83: 136-138. PMID: 38237134
- TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases. | Kratchmarov, R., et al. 2024. Nat Immunol. 25: 902-915. PMID: 38589618
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LEF-1 Antibody (REMB1) | sc-56722 | 100 µg/ml | $322.00 |