IL-8 Antibody (3E4D8): sc-32817

IL-8 Antibody (3E4D8) is a mouse monoclonal IgG1 antibody that detects interleukin-8 (IL-8) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. This function is particularly important in the context of chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis, where IL-8 levels are often elevated. The protein is initially synthesized as a 99 amino acid precursor, which is then cleaved to produce a biologically active 72 amino acid form. IL-8 exists in both monomeric and dimeric forms, with dimerization serving as a negative regulator of IL-8 receptor function, which is essential for modulating the immune response. The receptors for IL-8, IL-8RA and IL-8RB, are seven-transmembrane domain proteins that share a high degree of sequence identity and are also involved in the signaling of other chemokines. Anti-IL-8 antibody (3E4D8) is an invaluable tool for researchers studying the complex roles of IL-8 in inflammation and immune regulation.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IL-8 Antibody (3E4D8) References:

1. IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients.  |  Mendieta, D., et al. 2016. J Neuroimmunol. 290: 22-5. PMID: 26711564
2. IL-8, IL-8RA (CXCR1) and IL-8RB (CXCR2) expression in pilomatricoma.  |  Cianga, CM., et al. 2016. Rom J Morphol Embryol. 57: 59-64. PMID: 27151689
3. IL-8 as a potential biomarker in Guillain-Barre Syndrome.  |  Breville, G., et al. 2019. Eur Cytokine Netw. 30: 130-134. PMID: 32096474
4. ERK3/MAPK6 controls IL-8 production and chemotaxis.  |  Bogucka, K., et al. 2020. Elife. 9: PMID: 32314963
5. The IL-8-CXCR1/2 axis contributes to diabetic kidney disease.  |  Loretelli, C., et al. 2021. Metabolism. 121: 154804. PMID: 34097917
6. Effect of IL-8 on hepatocellular carcinoma-associated metastasis by targeting MMP9 in mice.  |  Xue, JC., et al. 2022. Transl Cancer Res. 11: 2050-2060. PMID: 36249885
7. IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.  |  Ma, Y., et al. 2022. Mol Immunol. 152: 111-122. PMID: 36327908
8. FAK/IL-8 axis promotes the proliferation and migration of gastric cancer cells.  |  Ma, Y., et al. 2023. Gastric Cancer. 26: 528-541. PMID: 36959335
9. Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.  |  K, J., et al. 2023. Monaldi Arch Chest Dis. 94: PMID: 37565285
10. Molecular interaction analysis of anti-IL-8 scFv-10F8-6His against IL-8 monomer through molecular docking and molecular dynamic simulations.  |  Abdul Kadir, FFN., et al. 2024. J Biomol Struct Dyn. 42: 12293-12303. PMID: 37837430

The preferred IL-8 antibody is IL-8 Antibody (C-11): sc-376750.