IL-1 alpha Antibody (3B3): sc-53350

IL-1α Antibody (3B3) is a mouse monoclonal IgG1 antibody that detects interleukin-1α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). IL-1α monoclonal antibody (3B3) recognizes a pivotal cytokine involved in the regulation of immune responses and inflammation, functioning primarily as an activator of T and B lymphocytes as well as natural killer (NK) cells. IL-1α (3B3) antibody targets a protein crucial for initiating and sustaining inflammatory processes, as IL-1α stimulates the production of interleukin-2 in T cells while selectively inhibiting interleukin-4 expression. IL-1α promotes B cell proliferation, maturation, and immunoglobulin synthesis, thereby enhancing the adaptive immune response. IL-1α (3B3) monoclonal antibody enables research into a protein implicated in various pathological conditions, including rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis, highlighting IL-1α′s potential as a therapeutic target. Anti-IL-1α antibody (3B3) serves as an essential tool for researchers investigating the complex mechanisms of immune regulation and inflammation in human health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IL-1 alpha Antibody (3B3) References:

1. Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes.  |  Mee, JB., et al. 2005. J Invest Dermatol. 124: 1267-74. PMID: 15955103
2. Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts.  |  Kawaguchi, Y., et al. 2006. Proc Natl Acad Sci U S A. 103: 14501-6. PMID: 16971486
3. Role of IL-1α in cisplatin-induced acute renal failure in mice.  |  Lee, JW., et al. 2011. Korean J Intern Med. 26: 187-94. PMID: 21716595
4. IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3.  |  Bastien, D., et al. 2015. J Neurosci. 35: 10715-30. PMID: 26224856
5. Interleukin-1 receptor antagonist inhibits angiogenesis via blockage IL-1α/PI3K/NF-κβ pathway in human colon cancer cell.  |  Ma, J., et al. 2017. Cancer Manag Res. 9: 481-493. PMID: 29062241
6. Developmentally Regulated Innate Immune NFκB Signaling Mediates IL-1α Expression in the Perinatal Murine Lung.  |  Butler, B., et al. 2019. Front Immunol. 10: 1555. PMID: 31354715
7. IL-1α Regulates Osteogenesis and Osteoclastic Activity of Dental Follicle Cells Through JNK and p38 MAPK Pathways.  |  Meng, M., et al. 2020. Stem Cells Dev. 29: 1552-1566. PMID: 33107399
8. Alendronate Augments Lipid A-Induced IL-1α Release via Activation of ASC but Not Caspase-11.  |  Tamai, R., et al. 2021. Inflammation. 44: 2132-2141. PMID: 34080091
9. Association between CILP and IL-1α polymorphisms and phenotype-dependent intervertebral disc degeneration susceptibility: A meta-analysis.  |  Liu, J., et al. 2022. Front Genet. 13: 1005393. PMID: 36276953
10. Correction for: Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells.  |  Jia, Y., et al. 2024. Aging (Albany NY). 16: 5792-5794. PMID: 38578657

The preferred IL-1α antibody is IL-1α Antibody (G-10): sc-271618.