IL-1 alpha Antibody (ALF-161): sc-12741

IL-1α Antibody (ALF-161) is a hamster monoclonal IgG antibody that detects IL-1α of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IL-1α Antibody (ALF-161) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-1α plays a pivotal role in the immune response and inflammation, acting as a key mediator that influences the activity of T and B lymphocytes as well as natural killer (NK) cells. IL-1α is primarily located in the cytoplasm of cells and can be released upon cell activation, which is crucial for mediating inflammatory responses. IL-1α presence in the cytoplasm allows for rapid release during inflammatory stimuli, enabling swift communication between immune cells and the surrounding tissue. IL-1α is involved in various physiological processes, including kidney development and cartilage degradation, and has been implicated in several pathological conditions such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis. IL-1α binding to the same receptor as IL-1β, despite their distinct genetic origins, underscores IL-1α importance in orchestrating a coordinated immune response.

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IL-1 alpha Antibody (ALF-161) References:

1. IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination.  |  Oleszycka, E., et al. 2016. FEBS J. 283: 9-24. PMID: 26536497
2. Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease.  |  Anders, HJ. 2016. J Am Soc Nephrol. 27: 2564-75. PMID: 27516236
3. Function and regulation of IL-1α in inflammatory diseases and cancer.  |  Malik, A. and Kanneganti, TD. 2018. Immunol Rev. 281: 124-137. PMID: 29247991
4. IL-1α Processing, Signaling and Its Role in Cancer Progression.  |  Chiu, JW., et al. 2021. Cells. 10: PMID: 33430381
5. Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases.  |  Cavalli, G., et al. 2021. Autoimmun Rev. 20: 102763. PMID: 33482337
6. Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis.  |  Wang, F., et al. 2022. Acta Pharm Sin B. 12: 3618-3638. PMID: 36176909
7. Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.  |  Chao, YY., et al. 2023. Nat Immunol. 24: 295-308. PMID: 36604548
8. Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren's syndrome.  |  Martín-Nares, E., et al. 2023. Clin Rheumatol. 42: 1101-1105. PMID: 36627528
9. Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells.  |  Oleszycka, E., et al. 2023. Front Immunol. 14: 1285357. PMID: 38090554
10. Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α.  |  Zhou, X., et al. 2024. Eur Heart J. 45: 2235-2250. PMID: 38607560

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1α Antibody (ALF-161) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1α Antibody (ALF-161) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1α Antibody (ALF-161) Specifications

Alternate Product Name: IL-1α

Product Clone Name: ALF-161

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: IL-1α

Epitope Species: mouse

Product Reactivity/Detection: IL-1α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for IL-1α Antibody (ALF-161): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin

The preferred IL-1α antibody is IL-1α Antibody (G-10): sc-271618.