IL-1 alpha Antibody (1F3B3): sc-32814

IL-1α Antibody (1F3B3) is a mouse monoclonal IgG antibody that detects interleukin-1α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-IL-1α antibody (1F3B3) recognizes a pivotal cytokine that plays a crucial role in mediating inflammatory responses and regulating immune functions. IL-1α is primarily produced by activated macrophages and is found in various tissues, including the brain, liver, and lungs, where IL-1α can influence local immune responses. IL-1α′s ability to bind to the IL-1 receptor initiates a cascade of signaling events that lead to the activation of immune cells, such as T and B lymphocytes, as well as natural killer cells. This activation is essential for the production of other cytokines, including IL-2, which is vital for T cell proliferation. IL-1α is involved in the pathogenesis of several inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, highlighting IL-1α′s importance as a therapeutic target. Anti-IL-1α antibody (1F3B3) serves as an invaluable tool for researchers studying the intricate roles of this cytokine in both health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

IL-1 alpha Antibody (1F3B3) References:

1. Altered expression of cytokines IL-1α, IL-6, IL-8 and TNF-α in bovine follicular persistence.  |  Stassi, AF., et al. 2017. Theriogenology. 97: 104-112. PMID: 28583593
2. IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β.  |  Lee, H., et al. 2018. Biomol Ther (Seoul). 26: 417-423. PMID: 29310426
3. Analysis of serum interleukin(IL)-1α, IL-1β and IL-18 in patients with systemic sclerosis.  |  Lin, E., et al. 2019. Clin Transl Immunology. 8: e1045. PMID: 30997045
4. IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media.  |  Serban, R., et al. 2021. Exp Ther Med. 22: 1226. PMID: 34539822
5. Nuclear localization of propiece IL-1α in HeLa cells.  |  Kudo, Y., et al. 2022. J Oral Sci. 64: 151-155. PMID: 35236814
6. IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases.  |  Frezza, V., et al. 2022. Front Immunol. 13: 879029. PMID: 35844537
7. Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy.  |  Rydberg Millrud, C., et al. 2023. Cancer Immunol Immunother. 72: 667-678. PMID: 36036818
8. IL-1α-releasing TH17 cells live long and prosper.  |  Groom, JR. and Vince, JE. 2023. Nat Immunol. 24: 205-206. PMID: 36658242
9. IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α.  |  Azumi, Y., et al. 2023. Cells. 12: PMID: 37998338
10. Tumor Cell-Associated IL-1α Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment.  |  Krishnamohan, M., et al. 2024. Int J Mol Sci. 25: PMID: 38612760

The preferred IL-1α antibody is IL-1α Antibody (G-10): sc-271618.