HVEM Antibody (CW10): sc-21718
- HVEM Antibody (CW10) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- epitope mapping to amino acids 120-200 of human HveA
- HVEM Antibody (CW10) is recommended for detection of HVEM of human origin by WB, IP, IF, IHC(P) and FCM
- HVEM Antibody (CW10) is available conjugated to agarose for IP; to HRP for WB, IHC(P) and ELISA; and to phycoerythrin for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for HVEM Antibody (CW10) for WB and IHC(P) applications. This reagent is now offered in a bundle with HVEM Antibody (CW10) (see ordering information below).
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HVEM Antibody (CW10) is a mouse monoclonal IgG1 kappa light chain antibody that detects HVEM of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HVEM Antibody (CW10) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. HVEM, or herpes virus entry mediator A, is a 283 amino acid single-pass type I membrane protein that plays a crucial role in immune response and viral pathogenesis. HVEM is predominantly expressed in lung, spleen, and thymus, where HVEM serves as a receptor for herpes simplex virus (HSV) glycoprotein D, facilitating viral entry into T lymphocytes. HVEM interacts with two important ligands: secreted lymphotoxin and LIGHT, a member of tumor necrosis factor (TNF) superfamily produced by activated T-cells. HVEM interaction with LIGHT is particularly significant as this interaction induces apoptosis and suppresses tumor formation, highlighting HVEM′s potential role in cancer immunology. Structurally, HVEM consists of three TNFR-Cys repeats, which are essential for function and interactions, and HVEM is encoded by a gene located on human chromosome 1, a region encompassing nearly 8% of the human genome and containing over 3,000 genes. This intricate relationship between HVEM and its ligands underscores HVEM′s importance in both immune regulation and viral pathogenesis, making anti-HVEM antibody (CW10) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HVEM Antibody (CW10) References:
- HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System. | Shui, JW. and Kronenberg, M. 2014. Immune Netw. 14: 67-72. PMID: 24851095
- Nectin-1 and HVEM: cellular receptors for HSV-1 in skin. | Knebel-Mörsdorf, D. 2016. Oncotarget. 7: 19087-8. PMID: 27031306
- BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer. | Demerlé, C., et al. 2021. Front Oncol. 11: 682007. PMID: 34532285
- The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases. | Wojciechowicz, K., et al. 2022. Cell Immunol. 376: 104532. PMID: 35537322
- Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy. | Sordo-Bahamonde, C., et al. 2023. Mol Cancer. 22: 142. PMID: 37649037
- LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation. | Gupta, RK., et al. 2024. J Autoimmun. 144: 103177. PMID: 38368767
- The BTLA-HVEM complex - The future of cancer immunotherapy. | Wojciechowicz, K., et al. 2024. Eur J Med Chem. 268: 116231. PMID: 38387336
- The role of the BTLA-HVEM complex in the pathogenesis of breast cancer. | Hu, X. 2024. Breast Cancer. 31: 358-370. PMID: 38483699
- The BTLA-HVEM axis restricts CAR T cell efficacy in cancer. | Guruprasad, P., et al. 2024. Nat Immunol. 25: 1020-1032. PMID: 38831106
- BTLA and HVEM: Emerging players in the tumor microenvironment and cancer progression. | Mohamed, AH., et al. 2023. Cytokine. 172: 156412. PMID: 39492110
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HVEM Antibody (CW10) | sc-21718 | 200 µg/ml | $322.00 | |||
HVEM Antibody (CW10): m-IgG Fc BP-HRP Bundle | sc-525501 | 200 µg Ab; 10 µg BP | $361.00 | |||
HVEM Antibody (CW10) AC | sc-21718 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HVEM Antibody (CW10) HRP | sc-21718 HRP | 200 µg/ml | $322.00 | |||
HVEM Antibody (CW10) PE | sc-21718 PE | 200 µg/ml | $349.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 488 | sc-21718 AF488 | 200 µg/ml | $364.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 546 | sc-21718 AF546 | 200 µg/ml | $364.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 594 | sc-21718 AF594 | 200 µg/ml | $364.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 647 | sc-21718 AF647 | 200 µg/ml | $364.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 680 | sc-21718 AF680 | 200 µg/ml | $364.00 | |||
HVEM Antibody (CW10) Alexa Fluor® 790 | sc-21718 AF790 | 200 µg/ml | $364.00 |