Histone Deacetylase 8 (HDAC8) Antibody (F-9): sc-374180

HDAC8 Antibody (F-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects Histone Deacetylase 8 (HDAC8) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HDAC8 antibody (F-9) is available in a non-conjugated form, allowing for versatile experimental use. HDAC8 is a crucial enzyme located in the nucleus, where HDAC8 plays a significant role in the regulation of gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. This deacetylation process is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression, differentiation, and apoptosis. Dysregulation of HDAC8 has been implicated in several diseases, including cancer, making HDAC8 an important target for therapeutic intervention. The unique tissue distribution of HDAC8, which differs from other histone deacetylases, highlights specific functional roles in various tissues and potential as a biomarker for certain pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Histone Deacetylase 8 (HDAC8) Antibody (F-9) References:

1. Development of a Potent and Selective HDAC8 Inhibitor.  |  Ingham, OJ., et al. 2016. ACS Med Chem Lett. 7: 929-932. PMID: 27774131
2. Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors.  |  Zhao, C., et al. 2018. Eur J Med Chem. 150: 282-291. PMID: 29533873
3. Structural exploration of tetrahydroisoquinoline derivatives as HDAC8 inhibitors through multi-QSAR modeling study.  |  Banerjee, S., et al. 2020. J Biomol Struct Dyn. 38: 1551-1564. PMID: 31074329
4. Development of decision trees to discriminate HDAC8 inhibitors and non-inhibitors using recursive partitioning.  |  Amin, SA., et al. 2021. J Biomol Struct Dyn. 39: 1-8. PMID: 31530244
5. HDAC8 promotes the dissemination of breast cancer cells via AKT/GSK-3β/Snail signals.  |  An, P., et al. 2020. Oncogene. 39: 4956-4969. PMID: 32499521
6. Discovery of novel HDAC8 inhibitors from natural compounds by in silico high throughput screening.  |  Esther Rubavathy, SM., et al. 2023. J Biomol Struct Dyn. 41: 9492-9502. PMID: 36369945
7. A comparative quantitative structural assessment of benzothiazine-derived HDAC8 inhibitors by predictive ligand-based drug designing approaches.  |  Banerjee, S., et al. 2022. SAR QSAR Environ Res. 33: 987-1011. PMID: 36533308
8. A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation.  |  Huang, Y., et al. 2024. Cell Chem Biol. 31: 514-522.e4. PMID: 38460516
9. Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.  |  Zhao, C., et al. 2024. J Med Chem. 67: 14016-14039. PMID: 39089850
10. Butyrate Inhibits the HDAC8/NF-κB Pathway to Enhance Slc26a3 Expression and Improve the Intestinal Epithelial Barrier to Relieve Colitis.  |  Peng, K., et al. 2024. J Agric Food Chem. 72: 24400-24416. PMID: 39440960

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 8 (HDAC8) Antibody (F-9) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 8 (HDAC8) Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 8 (HDAC8) Antibody (F-9) Specifications

Alternate Product Name: HDAC8

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 2-28

Epitope Target: HDAC8

Epitope Species: human

Product Reactivity/Detection: HDAC8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 8 (HDAC8) Antibody (F-9): P: Blocking Peptide

The preferred Histone Deacetylase 8 antibody is Histone Deacetylase 8 Antibody (E-5): sc-17778.