Date published: 2026-4-24

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Guaifenesin (CAS 93-14-1)

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Alternate Names:
Guaiacol glyceryl ether; Guaiphenesin
Application:
Guaifenesin is a compound with expectorant and sedative properties
CAS Number:
93-14-1
Purity:
≥98%
Molecular Weight:
198.22
Molecular Formula:
C10H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Guaifenesin functions as an expectorant in experimental applications. It acts by increasing the volume and reducing the viscosity of respiratory tract secretions, which helps to loosen and clear mucus from the airways. At the molecular level, guaifenesin works by stimulating the production and secretion of thinner mucus in the respiratory tract, making it easier to expel. Guaifenesin does not directly affect the underlying cause of respiratory conditions, but rather facilitates the removal of mucus from the airways. Guaifenesin′s mechanism of action involves altering the physical properties of mucus, making it less sticky and easier to cough up. Guaifenesin′s function in experimental applications involves its ability to modify the characteristics of respiratory secretions, aiding in the clearance of mucus from the airways.


Guaifenesin (CAS 93-14-1) References

  1. Guaifenesin enhances the analgesic potency of paracetamol in mice.  |  Dolezal, T. and Krsiak, M. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 551-4. PMID: 12444496
  2. Effect of guaifenesin on cough reflex sensitivity.  |  Dicpinigaitis, PV. and Gayle, YE. 2003. Chest. 124: 2178-81. PMID: 14665498
  3. Voltammetric assay of Guaifenesin in pharmaceutical formulation.  |  Tapsoba, I., et al. 2005. J Pharm Biomed Anal. 38: 162-5. PMID: 15907635
  4. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells.  |  Seagrave, J., et al. 2011. Exp Lung Res. 37: 606-14. PMID: 22044398
  5. Anesthetic induction with guaifenesin and propofol in adult horses.  |  Brosnan, RJ., et al. 2011. Am J Vet Res. 72: 1569-75. PMID: 22126682
  6. Hemolytic potential of guaifenesin in cattle.  |  Wall, R. and Muir, WW. 1990. Cornell Vet. 80: 209-16. PMID: 2318045
  7. Evaluation of developmental toxicity of guaifenesin using pregnant female rats.  |  Shabbir, A., et al. 2016. Indian J Pharmacol. 48: 264-9. PMID: 27298495
  8. Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation.  |  Kolbach-Mandel, AM., et al. 2017. Urolithiasis. 45: 139-149. PMID: 27435233
  9. Total intravenous anaesthesia with ketamine, medetomidine and guaifenesin compared with ketamine, medetomidine and midazolam in young horses anaesthetised for computerised tomography.  |  Pratt, S., et al. 2019. Equine Vet J. 51: 510-516. PMID: 30451308
  10. Electroanalytical Analysis of Guaifenesin on Poly(Acridine Orange) Modified Glassy Carbon Electrode and its Determination in Pharmaceuticals and Serum Samples.  |  Işık, H., et al. 2021. Comb Chem High Throughput Screen. 24: 376-385. PMID: 32646355
  11. High-Performance Liquid Chromatography Method for Simultaneous Determination of Guaifenesin, Salbutamol Sulfate and Guaifenesin Impurity (Guaiacol).  |  Naguib, IA., et al. 2021. J Chromatogr Sci. 59: 419-424. PMID: 33434919
  12. Multispectroscopic and molecular docking studies on DNA binding of guaifenesin drug.  |  Shahabadi, N. and Farhadi, R. 2021. Nucleosides Nucleotides Nucleic Acids. 40: 317-335. PMID: 33463400
  13. Heart rate, arterial pressure and propofol-sparing effects of guaifenesin in dogs.  |  Hristova, TS., et al. 2023. Vet Anaesth Analg. 50: 50-56. PMID: 36344374
  14. Guaifenesin alone or in combination with ketamine or sodium pentobarbital as an anesthetic in rabbits.  |  Olson, ME., et al. 1987. Can J Vet Res. 51: 383-6. PMID: 3651894
  15. Evaluation of xylazine, guaifenesin, and ketamine hydrochloride for restraint in horses.  |  Muir, WW., et al. 1978. Am J Vet Res. 39: 1274-8. PMID: 697134

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Guaifenesin, 25 g

sc-205710
25 g
$46.00

Guaifenesin, 100 g

sc-205710A
100 g
$145.00