GSDMDC1 Antibody (64-Y): sc-81868

GSDMDC1 Antibody (64-Y) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSDMDC1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-GSDMDC1 antibody (64-Y) is available as non-conjugated format. GSDMDC1, consisting of 484 amino acids, plays a crucial role in regulating cell death and inflammation, which is vital for maintaining tissue homeostasis and responding to cellular stress. GSDMDC1 function is particularly important in various diseases, including cancer, where dysregulation of cell death pathways can lead to tumor progression and resistance to therapy. GSDMDC1 gene is located on human chromosome 8, a region implicated in several genetic disorders and malignancies. Notably, alterations in chromosome 8, such as translocations and amplifications, are often associated with poor prognoses in leukemias and lymphomas. Understanding GSDMDC1′s role in these processes can provide insights into potential therapeutic targets and biomarkers for disease progression.

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GSDMDC1 Antibody (64-Y) References:

1. Chromosomes 8 and 10 workshop.  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
2. Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
3. Cytogenetic mapping of a novel locus for type II Waardenburg syndrome.  |  Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
4. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
5. DNA sequence and analysis of human chromosome 8.  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
6. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
7. Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis.  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSDMDC1 Antibody (64-Y) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-GSDMDC1 Antibody (64-Y) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSDMDC1 Antibody (64-Y) Specifications

Alternate Product Name: GSDMDC1

Product Clone Name: 64-Y

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-485

Epitope Target: GSDMDC1

Epitope Species: human

Product Reactivity/Detection: GSDMDC1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for GSDMDC1 Antibody (64-Y): N/A

The preferred GSDMDC1 antibody is GSDMDC1 Antibody (H-11): sc-393581.