GRK 7 Antibody (F-4): sc-398660
- GRK 7 Antibody (F-4) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 515-537 at the C-terminus of GRK 7 of human origin
- recommended for detection of GRK 7 of human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 7 Antibody (F-4) for WB applications. These reagents are now offered in bundles with GRK 7 Antibody (F-4) (see ordering information below).
GRK 7 Antibody (F-4) is a mouse monoclonal IgG2b antibody that detects GRK 7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRK 7, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization. This process is vital for maintaining cellular responsiveness to external signals, as it prevents overstimulation and allows for the fine-tuning of physiological responses. GRK 7 is predominantly located in the cytoplasm and can translocate to the plasma membrane upon receptor activation, highlighting its dynamic role in signal transduction. Understanding the function and regulation of GRK 7 is essential for elucidating the mechanisms underlying various physiological processes and potential pathologies, making GRK 7 (F-4) antibody an invaluable tool for researchers studying G protein-coupled receptor signaling pathways.
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GRK 7 Antibody (F-4) References:
- Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. | Weiss, ER., et al. 2001. J Neurosci. 21: 9175-84. PMID: 11717351
- Characterization of human GRK7 as a potential cone opsin kinase. | Chen, CK., et al. 2001. Mol Vis. 7: 305-13. PMID: 11754336
- M opsin phosphorylation in intact mammalian retinas. | Liu, P., et al. 2005. J Neurochem. 93: 135-44. PMID: 15773913
- Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. | Horner, TJ., et al. 2005. J Biol Chem. 280: 28241-50. PMID: 15946941
- Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. | Torisawa, A., et al. 2008. Photochem Photobiol. 84: 823-30. PMID: 18266817
- Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light. | Osawa, S., et al. 2008. J Neurochem. 107: 1314-24. PMID: 18803695
- Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP. | Chrispell, JD., et al. 2022. J Biol Chem. 298: 102636. PMID: 36273582
- Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction. | Otsuka, Y., et al. 2024. JCI Insight. 9: PMID: 38646933
- Novel gene fusions in human oropharyngeal carcinoma. | Masago, K., et al. 2024. Cancer Genet. 286-287: 29-34. PMID: 38971117
- The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. | Weiss, ER., et al. 1998. Mol Vis. 4: 27. PMID: 9852166
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 7 Antibody (F-4) | sc-398660 | 200 µg/ml | $322.00 | |||
GRK 7 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-536115 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRK 7 Antibody (F-4): m-IgG2b BP-HRP Bundle | sc-549515 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 7 (F-4) Neutralizing Peptide | sc-398660 P | 100 µg/0.5 ml | $69.00 |