Grim19 Antibody (1A8): sc-66195
- Grim19 Antibody (1A8) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant Grim19 of human origin
- recommended for detection of Grim19 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Grim19 Antibody (1A8). This work is in progress.
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Grim19 Antibody (1A8) is a mouse monoclonal IgG2a antibody that detects GRIM19 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GRIM19, also known as gene associated with retinoic-interferon-induced mortality 19 protein or cell death-regulatory protein GRIM-19, plays a crucial role in cellular processes by functioning as a tumor suppressor. GRIM19 is integral to the assembly and electron transfer activity of mitochondrial complex I, where GRIM19 facilitates the transfer of electrons from NADH to the respiratory chain, thereby supporting cellular respiration and energy production. Additionally, GRIM19 is involved in the interferon-beta and retinoic acid-induced pathway of apoptosis, highlighting GRIM19′s importance in regulating cell death and maintaining cellular homeostasis. The localization of GRIM19 primarily to the mitochondrion, with the potential to translocate to the nucleus upon treatment with interferon or retinoic acid, underscores GRIM19′s dynamic role in cellular signaling and response to stress. Given GRIM19′s dual functionality and involvement in critical pathways, GRIM19 may serve as a valuable biological marker and a target for therapeutic interventions in cancer treatment.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Grim19 Antibody (1A8) References:
- Construction of recombinant adenovirus carrying GRIM19 and its effect on SW480 cells. | Wang, S., et al. 2008. J Huazhong Univ Sci Technolog Med Sci. 28: 14-6. PMID: 18278448
- Grim19 Attenuates DSS Induced Colitis in an Animal Model. | Kim, JK., et al. 2016. PLoS One. 11: e0155853. PMID: 27258062
- GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation. | Park, MJ., et al. 2016. J Transl Med. 14: 206. PMID: 27391226
- Retinoid interferon-induced mortality19 (GRIM19) inhibits proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes. | Zhao, D., et al. 2018. Biomed Pharmacother. 98: 719-725. PMID: 29306209
- Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation. | Ni, F., et al. 2018. Cancer Chemother Pharmacol. 82: 593-605. PMID: 30032449
- Expressions and clinical significances of STAT3 and Grim19 in epithelial ovarian cancer. | Wang, Y., et al. 2020. 3 Biotech. 10: 246. PMID: 32411570
- GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance. | Jhun, J., et al. 2021. Cells. 10: PMID: 33467683
- GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions. | Geng, C., et al. 2021. Reproduction. 162: 385-395. PMID: 34590585
- GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis. | Liu, H., et al. 2022. Reprod Biomed Online. 44: 211-219. PMID: 34906422
- Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling. | Xu, X., et al. 2024. J Clin Transl Hepatol. 12: 539-550. PMID: 38974954
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grim19 Antibody (1A8) | sc-66195 | 200 µg/ml | $322.00 |