Fascin 1 Antibody (5G112): sc-71100
- Fascin 1 Antibody (5G112) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against Fascin purified from Hela cells of human origin
- recommended for detection of Fascin 1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Fascin 1 (D-10): sc-46675 for Fascin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Fascin 1 Antibody (5G112) for WB and IHC(P) applications. These reagents are now offered in bundles with Fascin 1 Antibody (5G112) (see ordering information below).
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Fascin 1 Antibody (5G112) is a mouse monoclonal IgG1 antibody that detects Fascin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Fascin is a crucial Actin-bundling protein that plays a significant role in the organization of the cytoskeleton, particularly in the formation of dynamic cellular structures like microspikes, stress fibers, and membrane ruffles. Fascin′s ability to bundle Actin microfilaments is essential for processes such as cell migration and adhesion, which are vital for tissue remodeling and wound repair. Fascin expression is particularly important in dendritic cells, aiding in their identification in both blood and tissue contexts. Furthermore, Fascin has been implicated as a potential prognostic factor in ovarian epithelial pathology, suggesting a role as a novel therapeutic target in ovarian cancer treatment. Anti-Fascin antibody (5G112) provides a reliable tool for researchers investigating Fascin in various biological processes and diseases, facilitating a deeper understanding of its function and potential as a biomarker.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fascin 1 Antibody (5G112) References:
- Fascin-1 is a novel biomarker of aggressiveness in some carcinomas. | Kulasingam, V. and Diamandis, EP. 2013. BMC Med. 11: 53. PMID: 23443037
- Fascin-1 as a biomarker and prospective therapeutic target in colorectal cancer. | Adams, JC. 2015. Expert Rev Mol Diagn. 15: 41-8. PMID: 25370828
- Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer. | Ling, XL., et al. 2015. Onco Targets Ther. 8: 1589-95. PMID: 26170694
- Fascin 1 promoted the growth and migration of non-small cell lung cancer cells by activating YAP/TEAD signaling. | Liang, Z., et al. 2016. Tumour Biol. 37: 10909-15. PMID: 26886283
- Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer. | Yang, L., et al. 2017. Genet Mol Res. 16: PMID: 28653739
- Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome. | Arlt, MJ., et al. 2019. BMC Cancer. 19: 83. PMID: 30654764
- Circulating Fascin 1 as a Promising Prognostic Marker in Adrenocortical Cancer. | Cantini, G., et al. 2021. Front Endocrinol (Lausanne). 12: 698862. PMID: 34248854
- The effect of fascin 1 inhibition on head and neck squamous cell carcinoma cells. | Wahab, A., et al. 2021. Eur J Oral Sci. 129: e12819. PMID: 34346523
- Fascin-1 and its role as a serological marker in prostate cancer: a prospective case-control study. | Tătaru, OS., et al. 2021. Future Sci OA. 7: FSO745. PMID: 34737886
- Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1. | Gest, C., et al. 2023. JHEP Rep. 5: 100691. PMID: 37153687
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fascin 1 Antibody (5G112) | sc-71100 | 200 µg/ml | $322.00 | |||
Fascin 1 Antibody (5G112): m-IgG Fc BP-HRP Bundle | sc-539347 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fascin 1 Antibody (5G112): m-IgG1 BP-HRP Bundle | sc-541428 | 200 µg Ab; 20 µg BP | $361.00 |