FAS-L Antibody (1.BB.37): sc-71096

FAS-L Antibody (1.BB.37) is a hamster monoclonal IgG antibody that detects FAS-L in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). FAS-L, or FAS ligand, plays a crucial role in the regulation of apoptosis, particularly in the immune system, where FAS-L mediates the interaction between cytotoxic T lymphocytes and target cells. This interaction is vital for the elimination of virus-infected or transformed cells, as FAS-L binds to its receptor, FAS, triggering a cascade of events that lead to programmed cell death. The ability of FAS-L to induce apoptosis is essential for maintaining immune homeostasis and preventing autoimmune responses, as FAS-L helps to eliminate activated lymphocytes after an immune response has been resolved. Furthermore, the expression of FAS-L on activated T cells allows for the targeted killing of cells that express FAS, thereby ensuring that only those cells that pose a threat to the organism are eliminated. FAS-L (1.BB.37) antibody is an invaluable tool for researchers studying the mechanisms of immune regulation and the pathways involved in cell death, providing insights into potential therapeutic targets for diseases characterized by dysregulated apoptosis.

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FAS-L Antibody (1.BB.37) References:

1. FAS and FAS-L expression by tumor cells and lymphocytes in breast carcinomas and their lymph node metastases.  |  Ioachim, HL., et al. 2005. Pathol Res Pract. 200: 743-51. PMID: 15792116
2. Role of Fas/Fas-L in vascular cell apoptosis.  |  Stoneman, VE. and Bennett, MR. 2009. J Cardiovasc Pharmacol. 53: 100-8. PMID: 19188840
3. Role of the Fas/Fas-L pathway-mediated apoptosis in inflammatory heart diseases and vasculature diseases.  |  Binah, O. 2009. J Cardiovasc Pharmacol. 53: 91-3. PMID: 19188842
4. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells.  |  Xu, B., et al. 2011. Environ Toxicol. 26: 86-92. PMID: 19852076
5. Expression levels of Fas/Fas-L mRNA in human brain glioma stem cells.  |  Tao, J., et al. 2012. Mol Med Rep. 5: 1202-6. PMID: 22344564
6. Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes.  |  Li, J., et al. 2014. Toxicol Mech Methods. 24: 609-15. PMID: 25258304
7. Fas-L promotes the stem cell potency of adipose-derived mesenchymal cells.  |  Solodeev, I., et al. 2018. Cell Death Dis. 9: 695. PMID: 29891848
8. FAS/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia.  |  Yu, S., et al. 2020. Int J Biol Macromol. 150: 449-458. PMID: 32027895
9. MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through Regulating the FAS/FAS-L Signaling Pathway.  |  Tang, H., et al. 2021. Int Heart J. 62: 647-657. PMID: 33994507
10. Expression of proapoptotic receptors Fas/Fas-L on sperm cells and levels of their soluble forms in seminal fluid from patients with varicocele.  |  Razeghinia, MS., et al. 2022. J Reprod Immunol. 149: 103443. PMID: 34837753

The preferred FAS-L antibody is FAS-L Antibody (NOK-1): sc-19681.