Edc3 Antibody (B-9): sc-271732

Edc3 Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects Edc3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Edc3, or enhancer of mRNA-decapping protein 3, is a crucial 508 amino acid protein encoded by the human gene EDC3, and plays a significant role in the regulation of mRNA decay, a vital process for maintaining cellular homeostasis and gene expression. Edc3 is primarily localized in the cytoplasm, particularly within processing bodies (PBs), where Edc3 participates in the mRNA degradation pathway by forming a complex with other key proteins, including hDcp1a, hDcp2a, RCK, and Edc4/HEDLS. The interaction of Edc3 with DCP1A and DDX6 is essential for the decapping process, which serves as a critical control point in mRNA turnover. Additionally, Edc3 has been shown to interact with TTP (zinc finger protein 36), a protein implicated in obesity-related metabolic complications, highlighting Edc3′s potential role in metabolic regulation. Anti-Edc3 antibody (B-9) is an invaluable tool for researchers studying mRNA decay mechanisms and their implications in various biological processes and diseases.

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Edc3 Antibody (B-9) References:

1. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis.  |  Rudolph, C., et al. 2007. Horm Metab Res. 39: 322-35. PMID: 17533573
2. Crystal structure of human Edc3 and its functional implications.  |  Ling, SH., et al. 2008. Mol Cell Biol. 28: 5965-76. PMID: 18678652
3. Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.  |  Harigaya, Y., et al. 2010. Mol Cell Biol. 30: 1446-56. PMID: 20086104
4. DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells.  |  Iio, A., et al. 2013. Biochim Biophys Acta. 1829: 1102-10. PMID: 23932921
5. Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds.  |  Walters, RW., et al. 2014. G3 (Bethesda). 4: 613-22. PMID: 24504254
6. Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells.  |  Kim, HS., et al. 2016. Oxid Med Cell Longev. 2016: 2594703. PMID: 27493704
7. Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors.  |  Gnawali, GR., et al. 2022. Med Chem Res. 31: 1154-1175. PMID: 36389181
8. Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation.  |  Ciancone, AM., et al. 2022. Cell Chem Biol. 29: 1709-1720.e7. PMID: 36476517
9. Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways.  |  Kumar, R., et al. 2024. bioRxiv.. PMID: 39257769
10. EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.  |  Vidya, E., et al. 2024. Cell Rep. 43: 114781. PMID: 39331503

The preferred Edc3 antibody is Edc3 Antibody (D-6): sc-365024.