EAAT2 Antibody (20): sc-135892
- EAAT2 Antibody (20) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 562-574 of EAAT2 of human origin
- recommended for detection of EAAT2 of mouse, rat and human origin by WB and IP
- See EAAT2 (E-1): sc-365634 for EAAT2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EAAT2 Antibody (20). This work is in progress.
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EAAT2 Antibody (20) is a mouse monoclonal IgG1 antibody that detects excitatory amino acid transporter 2 (EAAT2) in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). EAAT2 plays a crucial role in the central nervous system by facilitating the uptake of the neurotransmitter L-glutamate, which is vital for maintaining synaptic homeostasis and preventing excitotoxicity. Anti-EAAT2 antibody (20) targets this transporter predominantly in astrocytes, where EAAT2 helps regulate extracellular glutamate levels, thereby protecting neurons from damage caused by excessive glutamate accumulation. The proper functioning of EAAT2 is essential for normal neuronal signaling and overall brain health, as dysregulation of glutamate transport can lead to various neurological disorders, including epilepsy and neurodegenerative diseases. EAAT2 is known to interact with several proteins, including the scaffolding protein PSD-95, which is important for synaptic stability and signaling. EAAT2 (20) monoclonal antibody enables researchers to gain insights into the expression and regulation of this critical transporter, furthering our understanding of its role in both physiological and pathological conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EAAT2 Antibody (20) | sc-135892 | 50 µg/0.5 ml | $322.00 |