DMRT1 Antibody (SS6): sc-101024
- DMRT1 Antibody (SS6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant DMRT1 of human origin
- recommended for detection of DMRT1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DMRT1 Antibody (SS6). This work is in progress.
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DMRT1 Antibody (SS6) is a mouse monoclonal IgG1 antibody that detects DMRT1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). DMRT1, or Doublesex- and mab-3-related transcription factor 1, is a crucial 373 amino acid protein characterized by a highly conserved zinc finger-like DNA-binding motif known as the DM domain. Anti-DMRT1 antibody (SS6) recognizes a protein that plays a vital role in sexual development across vertebrates and invertebrates, with expression limited to the testis in humans, where DMRT1 is transported to the nucleus by karyopherin β1. DMRT1 is required for proper testis development and potentially involved in the formation of seminiferous tubules, which are essential for spermatogenesis. Notably, the gene encoding DMRT1 exhibits a gonad-specific and sexually dimorphic expression pattern during embryogenesis in mammals and birds, and hemizygosity of the DMRT1 gene can lead to abnormal testicular development and XY feminization. Additionally, DMRT1 is expressed as four isoforms due to alternative splicing, highlighting the complexity of regulation and function in sexual differentiation. DMRT1 (SS6) antibody serves as an invaluable tool for researchers studying the mechanisms of sexual development and related disorders.
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DMRT1 Antibody (SS6) References:
- A Wt1-Dmrt1 transgene restores DMRT1 to sertoli cells of Dmrt1(-/-) testes: a novel model of DMRT1-deficient germ cells. | Agbor, VA., et al. 2013. Biol Reprod. 88: 51. PMID: 23255335
- DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment. | Zhang, T., et al. 2016. PLoS Genet. 12: e1006293. PMID: 27583450
- Multifaceted DMRT1 Reveals Additional Roles in Spermatogenesis. | Gerhardt, K. 2016. Biol Reprod. 95: 111. PMID: 27881433
- The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming. | Lindeman, RE., et al. 2021. Nucleic Acids Res. 49: 6144-6164. PMID: 34096593
- Functional assessment of DMRT1 variants and their pathogenicity for isolated male infertility. | Emich, J., et al. 2023. Fertil Steril. 119: 219-228. PMID: 36572623
- Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility. | Zhang, MF., et al. 2023. Zool Res. 44: 505-521. PMID: 37070575
- DMRT1 drives the human germline forward. | Lu, Y., et al. 2023. Nat Cell Biol. 25: 1408-1410. PMID: 37709821
- DMRT1 regulates human germline commitment. | Irie, N., et al. 2023. Nat Cell Biol. 25: 1439-1452. PMID: 37709822
- DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility. | Dujardin, E., et al. 2023. Elife. 12: PMID: 37847154
- Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapia. | Qi, S., et al. 2024. PLoS Genet. 20: e1011210. PMID: 38536778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMRT1 Antibody (SS6) | sc-101024 | 100 µg/ml | $339.00 |