Cdc6 Antibody (DCS-180): sc-56273
- Cdc6 Antibody (DCS-180) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length Cdc6 of human origin
- recommended for detection of Cdc6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Cdc6 (180.2): sc-9964 for Cdc6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Cdc6 Antibody (DCS-180) for WB and IHC(P) applications. This reagent is now offered in a bundle with Cdc6 Antibody (DCS-180) (see ordering information below).
Cdc6 Antibody (DCS-180) is a mouse monoclonal IgG1 antibody that detects Cdc6 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cdc6 plays a crucial role in the initiation of DNA replication, acting as a regulatory factor that ensures proper timing of DNA synthesis during the cell cycle. Anti-Cdc6 antibody (DCS-180) recognizes a protein vital for maintaining genomic stability, as Cdc6 helps prevent premature or inappropriate DNA replication, which can lead to genomic instability and contribute to tumorigenesis. Cdc6 is primarily located in the nucleus, where Cdc6 associates with the origin recognition complex to facilitate helicase loading onto DNA, thereby marking sites for replication initiation. Understanding Cdc6 dynamics and regulatory mechanisms is essential for elucidating cell division processes and potential implications in cancer biology. Cdc6 (DCS-180) antibody serves as an invaluable tool for researchers studying cell cycle regulation and associated pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cdc6 Antibody (DCS-180) References:
- CDKs give Cdc6 a license to drive into S phase. | Ayad, NG. 2005. Cell. 122: 825-7. PMID: 16179249
- Cdc6: a trifunctional AAA+ ATPase that plays a central role in controlling the G(1)-S transition and cell survival. | Okayama, H. 2012. J Biochem. 152: 297-303. PMID: 22908236
- Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner. | Kim, GS., et al. 2015. Biochem Biophys Res Commun. 456: 763-7. PMID: 25498505
- SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication. | Walter, D., et al. 2016. Nat Commun. 7: 10530. PMID: 26818844
- The prognostic significance of Cdc6 and Cdt1 in breast cancer. | Mahadevappa, R., et al. 2017. Sci Rep. 7: 985. PMID: 28428557
- Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. | Youn, Y., et al. 2020. Sci Rep. 10: 16518. PMID: 33020506
- Increased CDC6 Expression Associates With Poor Prognosis in Patients With Clear Cell Renal Cell Carcinoma. | Yicong, Y., et al. 2021. Front Oncol. 11: 666418. PMID: 34136398
- LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway. | Li, J., et al. 2023. Mediators Inflamm. 2023: 9207148. PMID: 37501932
- The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex. | Geng, Y., et al. 2024. Int J Biol Macromol. 260: 129487. PMID: 38237821
- Cdc6 and DNA replication: limited to humble origins. | Heichman, KA. 1996. Bioessays. 18: 859-62. PMID: 8939063
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc6 Antibody (DCS-180) | sc-56273 | 200 µg/ml | $322.00 | |||
Cdc6 Antibody (DCS-180): m-IgG Fc BP-HRP Bundle | sc-551935 | 200 µg Ab; 10 µg BP | $361.00 |