CD74 Antibody (D-6): sc-137217
- CD74 Antibody (D-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 17-296 mapping at the C-terminus of CD74 of human origin
- recommended for detection of CD74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CD74 (LN-2): sc-6262 for CD74 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD74 Antibody (D-6) for WB and IHC(P) applications. These reagents are now offered in bundles with CD74 Antibody (D-6) (see ordering information below).
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CD74 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects CD74 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules, which are essential for presenting antigens to T lymphocytes. This process is vital for initiating adaptive immune responses, as CD74 allows the immune system to recognize and respond to pathogens effectively. CD74 is predominantly expressed in B lymphocytes and is also found in a subset of T lymphocytes, highlighting CD74′s importance in both humoral and cellular immunity. CD74 expression on these immune cells not only facilitates the proper functioning of MHC II but also serves as a marker for certain immune cell populations, making anti-CD74 antibody (D-6) an invaluable tool for researchers studying immune responses and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD74 Antibody (D-6) References:
- CD74 is a survival receptor on colon epithelial cells. | Maharshak, N., et al. 2010. World J Gastroenterol. 16: 3258-66. PMID: 20614481
- Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. | Fan, H., et al. 2011. J Immunol. 186: 4915-24. PMID: 21411731
- CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. | Zheng, YX., et al. 2012. World J Gastroenterol. 18: 2253-61. PMID: 22611320
- CD74: a potential novel target for triple-negative breast cancer. | Tian, B., et al. 2012. Tumour Biol. 33: 2273-7. PMID: 22935920
- Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. | Walline, CC., et al. 2014. Immunology. 141: 531-9. PMID: 24205828
- CD74/DQA1 dimers predispose to the development of arthritis in humanized mice. | David, L., et al. 2016. Immunology. 147: 204-11. PMID: 26524976
- Sensitivity and Specificity of Autoantibodies Against CD74 in Nonradiographic Axial Spondyloarthritis. | Riechers, E., et al. 2019. Arthritis Rheumatol. 71: 729-735. PMID: 30418704
- CD74, a novel predictor for bronchopulmonary dysplasia in preterm infants. | Gao, J., et al. 2020. Medicine (Baltimore). 99: e23477. PMID: 33235138
- The N-terminus of MIF regulates the dynamic profile of residues involved in CD74 activation. | Parkins, A., et al. 2021. Biophys J. 120: 3893-3900. PMID: 34437846
- Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma. | Valdez, CN., et al. 2024. Oncotarget. 15: 507-520. PMID: 39028303
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD74 Antibody (D-6) | sc-137217 | 200 µg/ml | $322.00 | |||
CD74 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-539962 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD74 Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-541817 | 200 µg Ab; 20 µg BP | $361.00 |