CD74 Antibody (By2): sc-20062
- CD74 Antibody (By2) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against B-cell lymphoma cells
- recommended for detection of CD74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- See CD74 (LN-2): sc-6262 for CD74 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD74 Antibody (By2) for WB and IHC(P) applications. These reagents are now offered in bundles with CD74 Antibody (By2) (see ordering information below).
QUICK LINKS
SEE ALSO...
CD74 Antibody (By2) is a mouse monoclonal IgG1 antibody that detects CD74 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules. This process is vital for the proper presentation of antigens to T lymphocytes, which is essential for initiating adaptive immune responses. The interaction between CD74 and MHC II occurs during the transport of MHC II to the endosomal compartment, where peptide binding takes place. Notably, CD74 is expressed in a wide range of immune cells, particularly in B lymphocytes, and CD74 expression is critical for the development and function of these cells. Understanding the role of CD74 in antigen presentation not only highlights CD74′s importance in immune responses but also underscores CD74′s potential as a therapeutic target in various diseases, including autoimmune disorders and cancers. Anti-CD74 antibody (By2) provides a reliable tool for researchers investigating the complexities of immune regulation and the mechanisms underlying immune-mediated diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD74 Antibody (By2) References:
- CD74 promotes perineural invasion of cancer cells and mediates neuroplasticity via the AKT/EGR-1/GDNF axis in pancreatic ductal adenocarcinoma. | Zhang, JF., et al. 2021. Cancer Lett. 508: 47-58. PMID: 33766751
- CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia. | Thavayogarajah, T., et al. 2022. Exp Hematol. 115: 30-43. PMID: 36096455
- Microglial CD74 Expression Is Regulated by TGFβ Signaling. | Jahn, J., et al. 2022. Int J Mol Sci. 23: PMID: 36142162
- A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models. | Chan, WK., et al. 2023. Exp Hematol Oncol. 12: 79. PMID: 37740214
- Vanillic acid alleviates liver fibrosis through inhibiting autophagy in hepatic stellate cells via the MIF/CD74 signaling pathway. | Qin, L., et al. 2023. Biomed Pharmacother. 168: 115673. PMID: 37857251
- Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients. | Westmeier, J., et al. 2023. Front Immunol. 14: 1236374. PMID: 37946732
- Single-cell RNA-seq reveals MIF-(CD74 + CXCR4) dependent inhibition of macrophages in metastatic papillary thyroid carcinoma. | Chen, W., et al. 2024. Oral Oncol. 148: 106654. PMID: 38061122
- MIF and CD74 as Emerging Biomarkers for Immune Checkpoint Blockade Therapy. | Fey, RM., et al. 2024. Cancers (Basel). 16: PMID: 38730725
- Single-cell transcriptome analysis deciphers the CD74-mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary disease. | Wang, D., et al. 2024. Clin Transl Med. 14: e1786. PMID: 39113235
- CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids. | Zhang, J., et al. 2024. FASEB J. 38: e70103. PMID: 39400419
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD74 Antibody (By2) | sc-20062 | 200 µg/ml | $322.00 | |||
CD74 Antibody (By2): m-IgG Fc BP-HRP Bundle | sc-536650 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD74 Antibody (By2): m-IgGκ BP-HRP Bundle | sc-533808 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD74 Antibody (By2): m-IgG1 BP-HRP Bundle | sc-544734 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD74 Antibody (By2) Alexa Fluor® 488 | sc-20062 AF488 | 200 µg/ml | $364.00 | |||
CD74 Antibody (By2) Alexa Fluor® 647 | sc-20062 AF647 | 200 µg/ml | $364.00 | |||
CD74 Antibody (By2) FITC | sc-20062 FITC | 200 µg/ml | $336.00 | |||
CD74 Antibody (By2) PE | sc-20062 PE | 200 µg/ml | $349.00 |