CD71/TFRC/Transferrin Receptor Antibody (OX26): sc-53059

CD71 Antibody (OX26) is a mouse monoclonal IgG2a antibody that detects CD71 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). CD71, also known as the transferrin receptor (TFR), plays a crucial role in iron homeostasis by facilitating the cellular uptake of transferrin-bound iron through receptor-mediated endocytosis. This process is vital for maintaining adequate iron levels, which are essential for numerous biological functions, including oxygen transport and DNA synthesis. CD71 is predominantly expressed on proliferating cells, reticulocytes, and erythroid precursors, while CD71 expression is upregulated in activated lymphocytes, monocytes, and macrophages, highlighting CD71′s importance in immune responses and cellular proliferation. Additionally, CD71 is present on brain endothelium, indicating CD71′s potential role in neurovascular functions. The presence of a second transferrin receptor, TFR2, which is primarily expressed in the liver and erythroid precursors, further underscores the complexity of iron regulation in the body. Mutations in the TFR2 gene can lead to hereditary hemochromatosis type III, an iron overload disorder, emphasizing the clinical significance of understanding CD71′s function and regulation. Anti-CD71 antibody (OX26) is an invaluable tool for researchers investigating iron metabolism and related disorders.

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.