CD1D Antibody (3H649): sc-70571
- CD1D Antibody (3H649) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against CD1D of human origin
- recommended for detection of CD1D of human origin by WB, IP, IF and IHC(P)
- See CD1D (C3D5): sc-19632 for CD1D antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD1D Antibody (3H649) for WB and IHC(P) applications. These reagents are now offered in bundles with CD1D Antibody (3H649) (see ordering information below).
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CD1D Antibody (3H649) is a mouse monoclonal IgG1 antibody that detects CD1D in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD1D is a crucial member of the CD1 multigene family, which encodes five forms of the CD1 T cell surface glycoprotein, and plays a significant role in the immune system by presenting lipid antigens to T lymphocytes. CD1D is primarily located on the surface of human intestinal epithelial cells, where CD1D exists in two forms: a β-2-Microglobulin-independent nonglycosylated form and a β-2-Microglobulin-dependent glycosylated form. CD1D expression on these cells is vital for the regulation of immune responses in the gut, influencing the maturation and activation of CD1-restricted T cells. The human CD1D gene is mapped to chromosome 1q23.1 and encodes a 335 amino acid protein that is essential for normal T cell development. Anti-CD1D antibody (3H649) is an invaluable tool for researchers studying immune responses, T cell maturation, and the role of lipid antigens in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD1D Antibody (3H649) References:
- Role and regulation of CD1d in normal and pathological B cells. | Chaudhry, MS. and Karadimitris, A. 2014. J Immunol. 193: 4761-8. PMID: 25381357
- CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides. | Nishioka, Y., et al. 2018. Front Immunol. 9: 548. PMID: 29599785
- Role of CD1d- and MR1-Restricted T Cells in Asthma. | Iwamura, C. and Nakayama, T. 2018. Front Immunol. 9: 1942. PMID: 30210497
- The Role of CD1d and MR1 Restricted T Cells in the Liver. | Huang, W., et al. 2018. Front Immunol. 9: 2424. PMID: 30425710
- CD1d deficiency limits tolerogenic properties of peritoneal macrophages. | Basri, F., et al. 2021. BMB Rep. 54: 209-214. PMID: 33407995
- CD1d expression demarcates CDX4+ hemogenic mesoderm with definitive hematopoietic potential. | Philip Creamer, J., et al. 2022. Stem Cell Res. 62: 102808. PMID: 35569347
- Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids. | Rudolph, M., et al. 2022. Front Immunol. 13: 897873. PMID: 35874748
- Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases. | Lee, SW., et al. 2022. Front Immunol. 13: 979370. PMID: 36119077
- Advanced omics techniques shed light on CD1d-mediated lipid antigen presentation to iNKT cells. | Morris, I., et al. 2023. Biochim Biophys Acta Mol Cell Biol Lipids. 1868: 159292. PMID: 36773690
- CD1d-Dependent Natural Killer T Cells Mediate Hypertension and Vascular Injury Through Interleukin-17A. | Xiao, X., et al. 2023. J Am Heart Assoc. 12: e029179. PMID: 37382154
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD1D Antibody (3H649) | sc-70571 | 200 µg/ml | $322.00 | |||
CD1D Antibody (3H649): m-IgG Fc BP-HRP Bundle | sc-539295 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD1D Antibody (3H649): m-IgG1 BP-HRP Bundle | sc-541387 | 200 µg Ab; 20 µg BP | $361.00 |