CD1B Antibody (CC40): sc-101832

CD1B Antibody (CC40) is a mouse monoclonal IgG1 antibody that detects CD1B in ovine and bovine species through flow cytometry (FCM). CD1B is a crucial member of the CD1 multigene family, which encodes glycoproteins that play a significant role in the immune response by presenting lipid antigens to T lymphocytes. CD1B is primarily located on the surface of antigen-presenting cells, including dendritic cells and B cells, where CD1B facilitates the recognition of lipid-based antigens, thereby influencing T cell activation and differentiation. CD1B′s proper functioning is vital for the immune system′s ability to respond to lipid antigens, which are often derived from pathogens. Additionally, CD1B′s interaction with β-2-Microglobulin is essential for stability and surface expression, ensuring effective antigen presentation to T cells. The human CD1 genes, including CD1B, are clustered on chromosome 1q 22-23, highlighting their evolutionary relationship and functional importance in immune regulation. Anti-CD1B antibody (CC40) is an invaluable tool for researchers studying immune responses in ovine and bovine models, providing insights into the mechanisms of lipid antigen presentation and T cell activation.

The preferred CD1B antibody is CD1B Antibody (O249): sc-19997.