CD1B Antibody (3F66): sc-70569

CD1B Antibody (3F66) is a mouse monoclonal IgG1 antibody that detects CD1B in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD1B is a crucial member of the CD1 multigene family, which encodes glycoproteins that play a significant role in the immune response by presenting lipid antigens to T lymphocytes. CD1B is primarily located on the surface of antigen-presenting cells, including dendritic cells and Langerhans cells, where CD1B facilitates the recognition of lipid-based antigens by T cells. CD1B′s proper localization is essential for effective immune surveillance and response, as CD1B ensures that lipid antigens are presented in the right cellular context, allowing for the activation of CD1-restricted T cells. Additionally, CD1B′s interaction with β-2-Microglobulin is vital for stability and surface expression, further underscoring CD1B′s importance in immune function. The human CD1 genes, including CD1B, are clustered on chromosome 1q 22-23, highlighting their evolutionary relationship and coordinated regulation. Anti-CD1B antibody (3F66) is an invaluable tool for researchers studying lipid antigen presentation and T cell activation in human immunology.

The preferred CD1B antibody is CD1B Antibody (O249): sc-19997.