Cardiotrophin-1 Antibody (AN-B3): sc-9991

Cardiotrophin-1 Antibody (AN-B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cardiotrophin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cardiotrophin-1 monoclonal antibody (AN-B3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cardiotrophin-1 (CT-1) is a crucial member of the interleukin-6 (IL-6) family of cytokines, which play a significant role in cell signaling through gp130 receptor complexes. CT-1 interaction with the leukemia inhibitory factor (LIF) receptor/gp130 complex induces hypertrophy in cardiac myocytes, highlighting CT-1′s role in cardiac health and development. CT-1 is predominantly expressed in the myocardium during cardiogenesis, promoting proliferation and survival of embryonic cardiomyocytes, suggesting CT-1′s vital role in gp130 activation during cardiac development. CT-1 is highly expressed in various tissues, including heart, prostate, ovary, and skeletal muscle, while lower levels are found in lung, kidney, pancreas, thymus, testis, and small intestine, indicating diverse biological functions across different organ systems.

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Cardiotrophin-1 Antibody (AN-B3) References:

1. Molecular cloning and expression of an IL-6 signal transducer, gp130.  |  Hibi, M., et al. 1990. Cell. 63: 1149-57. PMID: 2261637
2. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.  |  Pennica, D., et al. 1995. Proc Natl Acad Sci U S A. 92: 1142-6. PMID: 7862649
3. cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats.  |  Ishikawa, M., et al. 1996. Biochem Biophys Res Commun. 219: 377-81. PMID: 8604995
4. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization.  |  Pennica, D., et al. 1996. Cytokine. 8: 183-9. PMID: 8833032
5. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.  |  Wollert, KC. and Chien, KR. 1997. J Mol Med (Berl). 75: 492-501. PMID: 9253712
6. Update of gp130 cytokines in multiple myeloma.  |  Klein, B. 1998. Curr Opin Hematol. 5: 186-91. PMID: 9664158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cardiotrophin-1 Antibody (AN-B3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Cardiotrophin-1 Antibody (AN-B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cardiotrophin-1 Antibody (AN-B3) Specifications

Alternate Product Name: Cardiotrophin-1

Product Clone Name: AN-B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Cardiotrophin-1

Epitope Species: human

Product Reactivity/Detection: Cardiotrophin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Cardiotrophin-1 Antibody (AN-B3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin