Blk Antibody (9D10B7H6): sc-65939
- Blk Antibody (9D10B7H6) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant protein Blk of human origin
- recommended for detection of Blk of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Blk Antibody (9D10B7H6). This work is in progress.
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Blk Antibody (9D10B7H6) is a mouse monoclonal IgG1 antibody that detects Blk in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Blk, a member of the Src family of non-receptor tyrosine kinases, plays a crucial role in the signaling pathways of B lymphocytes, which are essential for the adaptive immune response. anti-Blk antibody (9D10B7H6) recognizes a protein primarily located in the cytoplasm that regulates B cell receptor signaling, influencing processes such as cell proliferation, differentiation, and survival. Proper functioning of Blk is vital for maintaining immune homeostasis, as dysregulation can lead to immunodeficiencies or autoimmune diseases. Blk is encoded by a gene located on chromosome 8p23.1 and consists of 505 amino acids, with expression restricted to B lymphocytes, highlighting a specific role in the immune system. Blk (9D10B7H6) antibody serves as an invaluable tool for researchers studying B cell biology and related immunological processes, providing insights into the mechanisms of immune regulation and potential therapeutic targets.
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Blk Antibody (9D10B7H6) References:
- Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseases. | Tsuchiya, N., et al. 2010. Nihon Rinsho Meneki Gakkai Kaishi. 33: 57-65. PMID: 20453440
- Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells. | Samuelson, EM., et al. 2012. Immunol Cell Biol. 90: 620-9. PMID: 21894171
- Association between BLK polymorphisms and susceptibility to SLE: A meta-analysis. | Song, GG. and Lee, YH. 2017. Z Rheumatol. 76: 176-182. PMID: 27067206
- BLK and BANK1 variants and interactions are associated with susceptibility for primary Sjögren's syndrome and with some clinical features. | Montúfar-Robles, I., et al. 2021. Cell Immunol. 363: 104320. PMID: 33756160
- BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder. | Yin, BW., et al. 2021. CNS Neurosci Ther. 27: 1549-1560. PMID: 34637583
- Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). | Fu, T., et al. 2022. Eur J Med Chem. 229: 114051. PMID: 34952433
- Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma. | Choi, S., et al. 2022. J Pathol Transl Med. 56: 281-288. PMID: 36128864
- Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response. | Li, WW., et al. 2023. PLoS Pathog. 19: e1011742. PMID: 37871014
- BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation. | Li, WW., et al. 2024. J Cell Biol. 223: PMID: 38078859
- Fyn, Blk, and Lyn kinase inhibitors: A mini-review on medicinal attributes, research progress, and future insights. | Kohal, R., et al. 2024. Bioorg Med Chem Lett. 102: 129674. PMID: 38408513
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Blk Antibody (9D10B7H6) | sc-65939 | 100 µg/ml | $322.00 |