Date published: 2026-8-1

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TWIK Antibodies

Santa Cruz Biotechnology features a diverse variety of TWIK Antibodies for studying two-pore domain potassium channels, specifically the TWIK family. TWIK Antibodies are validated for multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). TWIK channels play a crucial role in maintaining resting membrane potential and regulating cellular excitability, making them significant for neuronal and cardiac function. TWIK channel dysregulation has been linked to various pathophysiological conditions, emphasizing their importance in both basic and translational research. Understanding TWIK channel function can provide insights into cellular mechanisms and potential therapeutic targets. Ongoing research continues to reveal new aspects of TWIK channel regulation and their impact on cellular processes. Research into TWIK channels has expanded our knowledge of ion channel biology and membrane potential regulation. TWIK monoclonal antibodies from Santa Cruz Biotechnology enable researchers worldwide to advance scientific understanding of cellular function and disease mechanisms.

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TWIK Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

TWIK-1 Antibody (4D7)

sc-517040mouse IgG1 κ265-336 (h)WB, IP, ELISAm, r, h
2
(1)

TWIK-2 Antibody (H-6)

sc-376515mouse IgG1 κ29-61 (h)WB, IP, IF, ELISAm, r, h
1
(1)

TWIK siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

TWIK-1 siRNA (h)

sc-42349hGene SilencingN/A
1
(0)

TWIK-1 shRNA Plasmid (h)

sc-42349-SHhGene SilencingPuromycin
1
(0)

TWIK-1 shRNA (h) Lentiviral Particles

sc-42349-VhGene SilencingPuromycin
1
(0)

TWIK-1 siRNA (m)

sc-42350mGene SilencingN/A0
(0)

TWIK-1 shRNA Plasmid (m)

sc-42350-SHmGene SilencingPuromycin0
(0)

TWIK-1 shRNA (m) Lentiviral Particles

sc-42350-VmGene SilencingPuromycin0
(0)

TWIK-2 siRNA (h)

sc-42351hGene SilencingN/A
1
(0)

TWIK-2 shRNA Plasmid (h)

sc-42351-SHhGene SilencingPuromycin
1
(0)

TWIK-2 shRNA (h) Lentiviral Particles

sc-42351-VhGene SilencingPuromycin
1
(0)

TWIK-2 siRNA (m)

sc-42352mGene SilencingN/A0
(0)

TWIK-2 shRNA Plasmid (m)

sc-42352-SHmGene SilencingPuromycin0
(0)

TWIK-2 shRNA (m) Lentiviral Particles

sc-42352-VmGene SilencingPuromycin0
(0)

TWIK-3 siRNA (h)

sc-96794hGene SilencingN/A0
(0)

TWIK-3 shRNA Plasmid (h)

sc-96794-SHhGene SilencingPuromycin0
(0)

TWIK-3 shRNA (h) Lentiviral Particles

sc-96794-VhGene SilencingPuromycin0
(0)

TWIK CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

TWIK-1 CRISPR/Cas9 KO Plasmid (h)

sc-405238Gene Knockouth0
(0)

TWIK-1 HDR Plasmid (h)

sc-405238-HDRHomology Directed Repairh0
(0)

TWIK-1 CRISPR/Cas9 KO Plasmid (m)

sc-421243Gene Knockoutm0
(0)

TWIK-1 HDR Plasmid (m)

sc-421243-HDRHomology Directed Repairm0
(0)

TWIK-2 CRISPR/Cas9 KO Plasmid (h)

sc-407263Gene Knockouth0
(0)

TWIK CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

TWIK-1 Double Nickase Plasmid (h)

sc-405238-NICGene Knockouth0
(0)

TWIK-1 Double Nickase Plasmid (h2)

sc-405238-NIC-2Gene Knockouth0
(0)

TWIK-2 Double Nickase Plasmid (h)

sc-407263-NICGene Knockouth0
(0)

TWIK-2 Double Nickase Plasmid (h2)

sc-407263-NIC-2Gene Knockouth0
(0)