Molecular structure of Cytisine, CAS Number: 485-35-8
Cytisine (CAS 485-35-8)
Alternate Names:
Baptitoxin
Application:
Cytisine is an AChR agonist and potent ligand for many AChR subtypes
CAS Number:
485-35-8
Purity:
≥99%
Molecular Weight:
190.24
Molecular Formula:
C11H14N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pyridine-like alkaloid. Nicotine agonist. Potent ligand for many nAChR subtypes. Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities.
Cytisine (CAS 485-35-8) References
- Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice. | Tutka, P., et al. 2013. Pharmacol Rep. 65: 195-200. PMID: 23563038
- Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of ΔFosB in mice. | Sajja, RK. and Rahman, S. 2013. Alcohol. 47: 299-307. PMID: 23601929
- Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats. | Igari, M., et al. 2014. Neuropsychopharmacology. 39: 455-65. PMID: 23966067
- Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. | Tutka, P., et al. 2017. Psychopharmacology (Berl). 234: 281-291. PMID: 27778062
- Cytisine induces apoptosis of HepG2 cells. | Yu, L., et al. 2017. Mol Med Rep. 16: 3363-3370. PMID: 28713951
- Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. | Yu, L., et al. 2018. Oncol Rep. 39: 1475-1484. PMID: 29328482
- Neuroprotection of Cytisine Against Cerebral Ischemia-Reperfusion Injury in Mice by Regulating NR2B-ERK/CREB Signal Pathway. | Zhao, P., et al. 2018. Neurochem Res. 43: 1575-1586. PMID: 29948728
- Advances on the Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships of Cytisine Derivatives. | Huang, X. and Xu, H. 2020. Mini Rev Med Chem. 20: 369-395. PMID: 31686638
- Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis. | Qian, Z., et al. 2020. J Cell Mol Med. 24: 10112-10127. PMID: 32790170
- Determination of Cytisine and N-Methylcytisine from Selected Plant Extracts by High-Performance Liquid Chromatography and Comparison of Their Cytotoxic Activity. | Petruczynik, A., et al. 2020. Toxins (Basel). 12: PMID: 32872484
- Cytisine is neuroprotective in female but not male 6-hydroxydopamine lesioned parkinsonian mice and acts in combination with 17-β-estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons. | Zarate, SM., et al. 2021. J Neurochem. 157: 710-726. PMID: 33354763
- Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy. | Zheng, JJ., et al. 2021. Front Pharmacol. 12: 706225. PMID: 34248648
- Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine. | Ibrayev, MK., et al. 2022. Plants (Basel). 12: PMID: 36616266
Inhibitor of:
ALDH1A1, galectin-6, SLC7A12, UQCRC1, and UQCRHL.Activator of:
AChR α 3, AChR α 4, AChR α 6, AChR α 7, AChRα10, AChRα2, AChRα5, AChRα9, AChRβ, AChRβ1, AChRβ2, AChRε, AChRγ, AChRbeta2, C6orf134, CHRNB4, EG666827, Lynx1, and Vmn1r30.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytisine, 5 mg | sc-203015 | 5 mg | $56.00 | |||
Cytisine, 25 mg | sc-203015A | 25 mg | $190.00 |