Molecular structure of L-Tetrahydropalmatine, CAS Number: 483-14-7
L-Tetrahydropalmatine (CAS 483-14-7)
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Alternate Names:
(−)-Tetrahydropalmatine
Application:
L-Tetrahydropalmatine is An alkaloid that depletes neurotransmitters
CAS Number:
483-14-7
Purity:
≥98%
Molecular Weight:
355.43
Molecular Formula:
C21H25NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Tetrahydropalmatine is an alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters such as dopamine, noradrenaline and serotonin. L-Tetrahydropalmatine is an inhibitor of D3DR. L-Tetrahydropalmatine is an inhibitor of SR-1A.
L-Tetrahydropalmatine (CAS 483-14-7) References
- Determination of L-tetrahydropalmatine in human plasma by HPLC and pharmacokinetics of its disintegrating tablets in healthy Chinese. | Chao-Wu, L., et al. 2011. Eur J Drug Metab Pharmacokinet. 36: 257-62. PMID: 21633914
- L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. | Zhou, HH., et al. 2016. Neuroreport. 27: 476-80. PMID: 26981712
- l-tetrahydropalmatine reduces nicotine self-administration and reinstatement in rats. | Faison, SL., et al. 2016. BMC Pharmacol Toxicol. 17: 49. PMID: 27817750
- L-Tetrahydropalmatine Induces Apoptosis in EU-4 Leukemia Cells by Down-Regulating X-Linked Inhibitor of Apoptosis Protein and Increases the Sensitivity Towards Doxorubicin. | Li, S., et al. 2017. Curr Mol Med. 17: 236-245. PMID: 28721806
- l-tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK-TRAF6 interactions and inhibiting NF-κB and MAPK pathways. | Zhi, X., et al. 2020. J Cell Mol Med. 24: 785-798. PMID: 31725199
- L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy. | Li, C., et al. 2020. Biochem Pharmacol. 177: 114021. PMID: 32389634
- Targeting ERα degradation by L-Tetrahydropalmatine provides a novel strategy for breast cancer treatment. | Xia, X., et al. 2020. Int J Biol Sci. 16: 2192-2204. PMID: 32549765
- Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor expression in rats. | Jiang, WN., et al. 2020. Eur J Pharmacol. 884: 173397. PMID: 32717192
- Inhibitory effect of ketoconazole, quinidine and 1-aminobenzotriazole on pharmacokinetics of l-tetrahydropalmatine and its metabolite in rats. | Xiao, W., et al. 2021. Xenobiotica. 51: 447-454. PMID: 33347343
- Pharmacokinetic study of three different formulations of l-tetrahydropalmatine in brain tissues of rats. | Li, Y., et al. 2021. Biomed Chromatogr. 35: e5066. PMID: 33452741
- L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. | Yi, Y., et al. 2021. Toxicology. 459: 152853. PMID: 34252480
- D-L-tetrahydropalmatine as monoamine depletor. | Liu, GQ., et al. 1982. Arch Int Pharmacodyn Ther. 258: 39-50. PMID: 6182845
- Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis. | Lin, MT., et al. 1996. Clin Exp Pharmacol Physiol. 23: 738-42. PMID: 8886500
Inhibitor of:
D3DR, Ebola virus VP40, and SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Tetrahydropalmatine, 100 mg | sc-202203 | 100 mg | $214.00 | |||
L-Tetrahydropalmatine, 500 mg | sc-202203A | 500 mg | $482.00 |