MYH11 activators belong to a distinct chemical class known for their ability to modulate the activity of the MYH11 gene. MYH11, short for "myosin heavy chain 11," is a crucial protein involved in the contraction of smooth muscle cells. Smooth muscles are found in various organs and tissues throughout the body, including the blood vessels, airways, and gastrointestinal tract. The MYH11 gene encodes a myosin protein specifically expressed in smooth muscle cells, and its activation plays a fundamental role in regulating smooth muscle contraction. MYH11 activators, therefore, are compounds or molecules that exert an influence on MYH11 expression or function, ultimately impacting the contractility of smooth muscles.
The exact mechanisms through which MYH11 activators operate can vary, but they typically act at the molecular level. Some MYH11 activators may enhance the transcription or expression of the MYH11 gene, leading to increased production of the MYH11 protein. Others may directly interact with the MYH11 protein, altering its conformation or function to promote smooth muscle contraction. These activators can be of significant interest in scientific research and may have potential applications in understanding various physiological processes, such as vascular tone regulation, airway constriction, and gastrointestinal motility. Additionally, studying MYH11 activators can help elucidate the intricate signaling pathways and molecular events involved in smooth muscle function, contributing to a broader understanding of cellular biology and potentially paving the way for future developments in related fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can activate various signaling pathways. PKC activation can influence cellular processes, potentially affecting Zyxin's role in cytoskeletal organization and cell adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a Rho kinase (ROCK) inhibitor. By inhibiting ROCK, it can indirectly affect Zyxin by modulating the RhoA-ROCK pathway, which is involved in cytoskeletal dynamics and cell adhesion. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. It can modulate various signaling pathways, indirectly impacting Zyxin activity by affecting downstream signaling cascades. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. It can affect gene expression and potentially indirectly influence Zyxin by modulating the transcription of related genes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel is a microtubule stabilizer. By stabilizing microtubules, it indirectly affects Zyxin-related processes associated with cytoskeletal dynamics and cell morphology. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
Calpeptin is a calpain inhibitor. Calpains are calcium-dependent proteases that can cleave Zyxin. Inhibiting calpain activity may indirectly maintain Zyxin levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K (Phosphoinositide 3-kinase) inhibitor. By inhibiting PI3K, it can modulate downstream signaling pathways, potentially impacting Zyxin-associated cellular functions. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
EHT 1864 is a Rac1 inhibitor. By inhibiting Rac1, it can affect actin dynamics and cell motility, indirectly influencing Zyxin activity. | ||||||