ZSCAN18 Activators

Given the established function of ZSCAN18 in RNA polymerase II-specific transcriptional processes, activators for this transcription factor are primarily focused on agents capable of modulating gene expression, either by direct interference or through epigenetic alterations. Such agents like Retinoic Acid, Trichostatin A, and 5-Aza-2'-deoxycytidine exert control at different regulatory checkpoints of transcription, offering opportunities for indirect modulation of ZSCAN18 activity. For instance, Retinoic Acid, through its action on nuclear receptors, impacts the transcription of a suite of genes, including those influenced by or influencing ZSCAN18.

Epigenetic agents, particularly those influencing acetylation and methylation states of histones or DNA, are key contenders in the realm of ZSCAN18 modulation. Compounds such as VPA and SAHA, recognized for their HDAC properties, alter the acetylation landscape, subsequently influencing the transcriptional state of many genes. Similarly, agents like EPZ004777 and BIX 01294, which focus on methylation, can indirectly impact ZSCAN18 by shifting the transcriptional output of its target genes or even ZSCAN18 itself. The underlying premise here is that any chemical which has the ability to alter the transcriptional landscape in cells can, by extension, influence the activity and role of ZSCAN18 as a transcriptional regulator.