ZO-2 Activators
ZO-2 (Zonula Occludens-2) activators encompass a diverse range of chemical compounds that indirectly influence the expression, localization, and function of ZO-2, a critical component of tight junctions in epithelial and endothelial cells. These activators operate through various mechanisms, modulating signaling pathways and cellular processes that affect tight junction assembly and integrity. For example, TGF-β1, through its role in epithelial-mesenchymal transition (EMT), can upregulate ZO-2 expression, contributing to changes in cellular architecture and function. Similarly, Retinoic Acid, by enhancing cellular differentiation and barrier functions, indirectly influences ZO-2's role in maintaining tight junction integrity.
The chemical class of ZO-2 activators is characterized by their ability to interact with multiple signaling pathways, demonstrating the interconnected nature of cellular signaling networks. Compounds like Forskolin and Y-27632 exemplify this by modulating cAMP levels and ROCK activity, respectively, thereby affecting ZO-2 indirectly. Forskolin elevates intracellular cAMP, a secondary messenger that plays a pivotal role in regulating tight junction assembly, which in turn can modulate ZO-2 expression and localization. On the other hand, Y-27632, as a ROCK inhibitor, alters cytoskeletal dynamics, which are crucial for the structural organization of tight junctions and the proper localization of ZO-2. This broad range of activators highlights the complex regulatory mechanisms governing ZO-2's function in cellular junctions and underscores the importance of a multifaceted approach in studying and modulating ZO-2 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid influences ZO-2 by modulating cellular differentiation and enhancing barrier function in epithelial tissues. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin enhances intracellular cAMP levels, indirectly influencing ZO-2 expression and tight junction integrity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK inhibitor, can indirectly affect ZO-2 by altering cytoskeletal dynamics and tight junction assembly. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can modulate ZO-2 expression by influencing inflammation and immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can indirectly influence ZO-2 localization and function in tight junctions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, can have an indirect effect on ZO-2 through the PI3K/Akt pathway, affecting cell survival and junction stability. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly influences ZO-2 by modulating cell growth and protein synthesis pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate influences ZO-2 expression through histone deacetylase inhibition, affecting gene expression and cellular differentiation. | ||||||