ZnT-9 Activators
ZnT-9 activators encompass a group of chemicals designed to modulate the activity of the protein ZnT-9, also known as SLC30A9, which is a member of the solute carrier family 30 that functions as a zinc transporter. ZnT-9 is implicated in the intracellular trafficking of zinc ions, which are essential for numerous biological processes, including enzyme activity, protein folding, and gene expression. The precise physiological role of ZnT-9 remains to be fully elucidated, but it is thought to be involved in the mobilization and compartmentalization of zinc within cellular organelles.
Direct activators of ZnT-9 typically bind to the protein and induce a conformational change that increases its zinc transport activity. This can involve stabilizing the protein in an open conformation that facilitates zinc ion translocation or enhancing the protein's affinity for zinc ions, thereby accelerating the rate of ion transport. Such direct interactions might also prevent the protein from adopting a conformation that is less active or prone to degradation. Indirect activators may work by influencing the expression levels of the ZnT-9 gene, stabilizing the ZnT-9 mRNA, or modulating the post-translational modifications of the protein that affect its stability and localization within the cell. They might also alter the cellular zinc status, increasing the availability of zinc ions to the transporter, or affect the cellular signaling pathways that regulate the function of zinc transporters in response to changes in intracellular and extracellular zinc concentrations.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate can increase intracellular zinc levels, which might activate ZnT-9, a zinc transporter, to facilitate zinc efflux to maintain cellular zinc homeostasis. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate can increase intracellular copper levels, triggering a cellular response to maintain metal ion homeostasis and possibly activate ZnT-9 to increase zinc efflux as an indirect response. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride increases intracellular cadmium levels, indirectly influencing ZnT-9, which may increase its activity to regulate zinc homeostasis against the perturbation caused by cadmium. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite increases intracellular arsenic levels, indirectly influencing ZnT-9, which could respond by increasing its activity to balance intracellular zinc levels. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $72.00 $107.00 | ||
Iron(II) sulfate increases intracellular iron levels, which could trigger ZnT-9 to enhance its activity in maintaining zinc homeostasis as part of the cellular response to elevated levels of metal ions. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Sodium selenite increases intracellular selenium levels, indirectly influencing ZnT-9, which may respond by increasing its activity to maintain zinc homeostasis. | ||||||
Nickel Sulfate | 7786-81-4 | sc-507407 | 5 g | $63.00 | ||
Nickel(II) sulfate increases intracellular nickel levels, indirectly influencing ZnT-9. ZnT-9 may enhance its activity to maintain zinc homeostasis as part of the cellular response to elevated levels of metal ions. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese(II) chloride increases intracellular manganese levels, indirectly influencing ZnT-9, which may increase its activity to regulate zinc homeostasis against the perturbation caused by manganese. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride increases intracellular lithium levels, which might trigger ZnT-9 to increase its activity in maintaining zinc homeostasis as an indirect response. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $112.00 $371.00 $1060.00 | 1 | |
Silver nitrate increases intracellular silver levels, indirectly influencing ZnT-9, which may respond by increasing its activity to maintain zinc homeostasis against the perturbation caused by silver. | ||||||