ZNFX1 Activators
ZNFX1 activators represent a collection of chemical compounds that indirectly promote the functional activity of ZNFX1 through specific signaling pathways integral to RNA surveillance and immune response mechanisms. Compounds such as Forskolin and Rolipram elevate intracellular cAMP levels, leading to PKA activation, which may phosphorylate proteins that interact with ZNFX1, thus potentiating its role in antiviral RNA processing. Similarly, PMA, through PKC activation, and Epigallocatechin gallate, by inhibiting various protein kinases, could modify the phosphorylation landscape to favor ZNFX1's function in RNA surveillance. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium, potentially enhancing ZNFX1 by activating calmodulin-dependent pathways that influence RNA binding and processing activities integral to ZNFX1's immune function.
Further, through the modulation of distinct signaling pathways, other activators help fine-tune the cellular environment to augment ZNFX1's activity. Genistein, by inhibiting tyrosine kinases, could alleviate signaling competition, thereby indirectly enhancing ZNFX1-mediated immune surveillance of RNA. Sphingosine-1-phosphate, which acts on G-protein-coupled receptors, is thought to influence RNA metabolism and immune response pathways, thereby indirectly promoting ZNFX1 activity. Lastly, Thapsigargin's inhibition of SERCA pumps heightens cytosolic calcium levels, which can activate calcium-dependent signaling pathways, potentially resulting in an upsurge of ZNFX1's role in RNA surveillance and immune system activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing the intracellular levels of cAMP. Elevated cAMP activates PKA, which can phosphorylate substrates that contribute to the regulation of nuclear RNA surveillance, potentially enhancing ZNFX1 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a PKC activator, which is involved in signal transduction pathways that can lead to the phosphorylation of proteins associated with RNA metabolism, thereby indirectly enhancing the functional activity of ZNFX1 in RNA surveillance. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, raising intracellular calcium levels which activate calmodulin-dependent pathways, potentially affecting the RNA binding capacity and function of ZNFX1 in immune-related RNA processing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels. The subsequent activation of PKA could enhance ZNFX1 function by influencing proteins that interact with ZNFX1 in the context of viral RNA sensing. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, elevating intracellular calcium levels and activating calcium-dependent signaling pathways. These pathways could enhance the RNA processing activities of ZNFX1 as part of the cellular immune response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which may enhance ZNFX1 activity by reducing tyrosine kinase-mediated signaling competition, thus favoring pathways where ZNFX1 is implicated in the immune surveillance of RNA. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages with G-protein-coupled receptors, potentially influencing pathways that regulate RNA metabolism and immune response, which could indirectly enhance the activity of ZNFX1 in identifying and binding to viral RNA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit several protein kinases, which may shift the equilibrium of cellular signaling to favor the activation of pathways where ZNFX1 is involved in RNA surveillance and processing within the immune response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels. This can activate calcium-dependent signaling pathways, potentially enhancing ZNFX1's role in RNA surveillance and processing mechanisms. | ||||||