ZNF91 Activators
Chemical activators of ZNF91 can regulate its activity via diverse cellular signaling pathways by modulating the phosphorylation status of the protein. Phorbol 12-myristate 13-acetate is one such activator, known for its role in activating protein kinase C (PKC). PKC plays a pivotal role in a multitude of intracellular signaling cascades and can directly phosphorylate ZNF91, altering its activity. Forskolin, another activator, operates by increasing intracellular cAMP, which in turn activates protein kinase A (PKA). PKA can then phosphorylate ZNF91, potentially altering its DNA-binding affinity and modulating its function. Ionomycin functions by raising intracellular calcium levels, which activates calcium-dependent protein kinases capable of phosphorylating ZNF91. Thapsigargin works indirectly by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium concentration and subsequent activation of kinases that target ZNF91 for phosphorylation.
Additionally, Calyculin A and Okadaic Acid inhibit protein phosphatases 1 and 2A, enzymes responsible for dephosphorylating proteins within the cell. Their inhibition results in the sustained phosphorylation of proteins, including ZNF91, which maintains ZNF91 in an activated state. Anisomycin activates stress-activated protein kinases (SAPKs), which are known to phosphorylate regulatory proteins involved in gene expression, and this could include ZNF91. Staurosporine and Bisindolylmaleimide I, while typically kinase inhibitors, can under certain conditions activate PKC, leading to the phosphorylation of ZNF91. Dibutyryl-cAMP, a synthetic analog of cAMP, can activate PKA, which then targets ZNF91 for phosphorylation. H-89, a PKA inhibitor, can paradoxically result in the activation of PKA through compensatory cellular mechanisms, leading to the activation of ZNF91. Lastly, Epigallocatechin gallate (EGCG) can modulate kinase signaling pathways and, despite its well-known role as an inhibitor, may activate kinases that phosphorylate ZNF91.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate activates protein kinase C (PKC) which can phosphorylate ZNF91, leading to its activation. PKC is integral to many signaling pathways and its activation is known to have downstream effects on DNA-binding proteins, which include zinc finger proteins like ZNF91. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which activates protein kinase A (PKA). PKA phosphorylation can lead to the activation of ZNF91 by modifying its interaction with DNA or other proteins, as PKA-mediated phosphorylation is a common regulatory mechanism for many transcription factors. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium concentration and activates calcium-dependent protein kinases, which could phosphorylate ZNF91 and induce its activation. Calcium signaling is critical for many cellular processes and can lead to the activation of proteins involved in gene regulation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular calcium by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), indirectly leading to the activation of calcium-dependent kinases that could phosphorylate and activate ZNF91. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins. This sustained phosphorylation could include ZNF91, resulting in its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, a potent inhibitor of protein phosphatases 1 and 2A, can cause the accumulation of phosphorylated proteins. This can lead to the activation of ZNF91 by maintaining its phosphorylated, active state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs). These kinases can phosphorylate substrates involved in gene regulation, potentially including ZNF91, leading to its activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, albeit generally a kinase inhibitor, can under certain conditions activate PKC which in turn can phosphorylate and activate ZNF91. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC, but it can also act as an activator under certain circumstances, potentially leading to the phosphorylation and activation of ZNF91 through PKC-mediated signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA which then can phosphorylate and activate ZNF91, influencing its role in gene regulation. | ||||||