ZNF77 Activators
Chemical activators of ZNF77, a transcription factor, are not directly interacting with the protein but rather influence the regulatory mechanisms that control the expression and activity of ZNF77. The selected compounds operate through various pathways like DNA methylation, histone modification, and signal transduction, which are crucial for gene expression regulation. For instance, 5-Azacytidine and Trichostatin A are chemicals that modify the epigenetic landscape; the former by DNA demethylation and the latter by histone deacetylation inhibition, both potentially enhancing the transcription of a range of genes including ZNF77.
In addition, compounds like resveratrol and sulforaphane can initiate a cascade of events through their effects on cellular stress response pathways, leading to modifications in gene expression. Retinoic acid and beta-Estradiol, by acting through their respective receptors, can induce gene transcription selectively. Similarly, inhibitors like PD98059 and LY294002 do not act on ZNF77 directly but modulate key signaling pathways such as MAPK/ERK and PI3K/Akt, which have downstream effects on gene expression profiles, including those of transcription factors.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into DNA and inhibits DNA methyltransferases, leading to hypomethylation of DNA and potential upregulation of genes including ZNF77. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that alters chromatin structure, thereby potentially increasing the expression of certain zinc finger proteins like ZNF77. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that can activate SIRT1, leading to changes in chromatin structure and influencing the expression of various genes, potentially including ZNF77. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A that regulates gene expression through its nuclear receptors, potentially affecting ZNF77 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
An antineoplastic antibiotic that binds to GC-rich sequences in DNA, preventing transcription factors from binding and potentially changing the expression patterns of genes including ZNF77. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK); by altering JNK activity, it can modulate transcription factor activity and potentially upregulate ZNF77 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that interferes with the MAPK/ERK pathway; by modulating this pathway, it may influence the expression of transcription factors like ZNF77. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, which by altering the PI3K/Akt signaling pathway, can affect the transcription of various genes, possibly including ZNF77. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A short-chain fatty acid and HDAC inhibitor that can cause hyperacetylation of histones, thereby potentially increasing the expression of ZNF77. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Through its active form, it can regulate gene expression via the vitamin D receptor, potentially affecting ZNF77 transcription. | ||||||