ZNF652 Activators
ZNF652 Activators are a series of chemical compounds that indirectly promote the functional activity of ZNF652 by interfacing with various cellular signaling pathways and regulatory mechanisms. Forskolin, by increasing cAMP levels, could potentially enhance the DNA-binding activity of ZNF652 through PKA-mediated phosphorylation of associated substrates. Ionomycin elevates intracellular calcium, which may activate calmodulin-dependent kinases, potentially facilitating ZNF652's regulatory role in gene expression. PMA, as an activator of PKC, may phosphorylate transcriptional co-regulators, potentially increasing ZNF652's transcriptional activity. 5-Azacytidine and Trichostatin A both act epigenetically, the former by reducing DNA methylation and the latter by promoting histone acetylation, which might result in enhanced ZNF652-mediated transcriptional regulation due to changes in chromatin accessibility and structure.
Continuing the enhancement of ZNF652, Retinoic acid could alter gene expression patterns in a way that favors ZNF652's regulatory functions. Epigallocatechin gallate, by inhibiting certain kinases, might reduce phosphorylation-based inhibition of ZNF652's co-regulators, leading to an indirect upregulation of ZNF652's functional activity. Sodium Butyrate, another histone deacetylase inhibitor, likely promotes a transcriptionally permissive chromatin state, enhancing ZNF652's regulatory potential. Curcumin's inhibition of NF-κB signaling could reduce competitive binding of transcriptional co-regulators, potentially freeing more to interact with ZNF652. Resveratrol, through SIRT1 activation, may alter the acetylation status of proteins in the ZNF652 complex, impacting its function. Pioglitazone, a PPAR-gamma agonist, and Lithium Chloride, a GSK-3 inhibitor, both could influence gene expression in a manner that upregulates ZNF652's transcriptional program, thereby enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins, potentially enhancing the DNA-binding activity of ZNF652 as part of its role in transcriptional regulation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent protein kinases, which may enhance the functional activity of ZNF652 by promoting its interaction with other co-regulators involved in gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activation of PKC can lead to phosphorylation of transcription factors and co-regulators, potentially augmenting the transcriptional regulatory functions of ZNF652. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that reduces DNA methylation, potentially leading to the demethylation of the ZNF652 gene promoter, thereby enhancing the transcriptional activity of ZNF652 without affecting its direct translation or transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a more open chromatin structure. This may enhance the accessibility of ZNF652 to its target DNA sequences, increasing its regulatory potential on gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, through its receptor, influences gene expression patterns. It can enhance the activity of ZNF652 by altering the transcriptional landscape and potentially increasing the expression of genes that ZNF652 co-regulates. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that might inhibit kinases that phosphorylate inhibitory sites on co-regulators of ZNF652, thereby enhancing ZNF652's role in gene expression by relieving the inhibition. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor, potentially increasing the transcriptional activity of ZNF652 by promoting a more relaxed chromatin state around genes that ZNF652 regulates. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which may lead to reduced competition for co-regulatory proteins that also interact with ZNF652, potentially enhancing ZNF652's ability to regulate its target genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), an NAD-dependent deacetylase, which may influence the activity of ZNF652 by altering the acetylation status of proteins involved in its regulatory complex. | ||||||