ZNF646 Inhibitors
Disulfiram and cisplatin engage in interactions with metal ions and DNA, respectively. Disulfiram's binding with metal ions can modify the structural integrity of zinc finger domains in proteins like ZNF646, thereby affecting their DNA-binding affinity. Cisplatin, by forming DNA adducts, can hinder transcription factor access to DNA, potentially disrupting ZNF646-DNA interactions essential for its function.
Chloroquine and MG132 target autophagic degradation and the ubiquitin-proteasome system, which are pivotal for protein turnover. By modulating these pathways, these compounds can influence ZNF646 levels indirectly. PD98059, LY294002, and SP600125 are kinase pathway inhibitors that impinge upon cell signaling cascades, which can modulate the activity and stability of transcription factors, potentially impacting ZNF646-regulated gene expression. Curcumin's wide-ranging effect on signaling pathways and transcription factors could extend to the modulation of ZNF646 function, given its pleiotropic nature. Lastly, alpha-amanitin inhibits RNA polymerase II, which is responsible for transcribing mRNA. By suppressing mRNA synthesis, alpha-amanitin can affect the transcriptional engagement of ZNF646 with its target genes.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that alters chromatin structure and gene expression, possibly affecting the transcription regulation by ZNF646. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that can lead to hypomethylation of DNA and affect gene expression patterns, potentially influencing ZNF646 target genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Histone deacetylase inhibitor that can change gene expression and may interfere with the transcriptional repression activities of ZNF646. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Aldehyde dehydrogenase inhibitor that also binds to copper and can form a complex with zinc fingers, potentially altering ZNF646's binding to DNA. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Chemotherapeutic agent that forms DNA adducts and could disrupt DNA binding of transcription factors like ZNF646. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Lysosomotropic agent that may affect cellular processes such as autophagy, which can influence the turnover of various proteins including ZNF646. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can prevent the degradation of proteins, potentially affecting the levels of ZNF646 if it is normally ubiquitinated and degraded. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that can block the MAPK/ERK pathway, which may be involved in the regulation of transcription factors, including ZNF646. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that affects the AKT signaling pathway and could impact transcription factors and their associated genes, potentially including those regulated by ZNF646. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that may alter transcription factor activity, possibly affecting ZNF646 function. | ||||||