ZNF571 Activators
ZNF571 can influence the protein in various ways, primarily through the modulation of intracellular signaling pathways and direct interactions that affect the protein's structure and function. Forskolin, through its direct activation of adenylyl cyclase, increases cellular cAMP levels, which in turn activates PKA. PKA then phosphorylates transcription factors or other proteins that can interact with ZNF571, enhancing its activity. Similarly, IBMX raises cAMP levels by inhibiting phosphodiesterases that would otherwise degrade cAMP, thus sustaining PKA activation and supporting the phosphorylation of proteins associated with ZNF571. PMA, by activating PKC, initiates a cascade that leads to the phosphorylation of relevant proteins that can interact with ZNF571, altering its functional state. Zinc sulfate provides zinc ions, which are crucial for the structural integrity and DNA-binding capability of ZNF571, thereby enhancing its transcription factor activity.
Other activators work by modulating cellular processes and signaling pathways that indirectly influence ZNF571 activity. Chloroquine, by increasing endosomal pH, can affect signaling pathways that lead to the activation of transcription factors or cofactors associated with ZNF571. Epigallocatechin gallate has the ability to modulate kinase activity, potentially altering the phosphorylation state of proteins that interact with ZNF571, thus promoting its activity. Spermidine, a polyamine, can affect signaling pathways involved in growth and differentiation, which may have an impact on ZNF571 function. Curcumin engages various kinases and signaling pathways, influencing the phosphorylation and cofactor availability necessary for ZNF571 activation. Resveratrol interacts with sirtuins and AMPK, which may influence the activity of ZNF571. Sodium butyrate, as a histone deacetylase inhibitor, can alter chromatin structure, potentially facilitating ZNF571 access to DNA. Vitamin D3 activates the VDR, which can interact with ZNF571, enhancing its function. Lastly, lithium chloride inhibits GSK-3, potentially stabilizing and enhancing the activity of transcription factors and cofactors that interact with ZNF571, thereby supporting its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, thereby preventing the breakdown of cAMP. This results in increased cAMP levels, potentially enhancing the PKA signaling pathway, which may lead to phosphorylation of proteins that interact with ZNF571 or components of the machinery that ZNF571 regulates, thus promoting the functional activity of ZNF571. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is involved in various signaling pathways. Activation of PKC can lead to the phosphorylation of proteins that may either interact with ZNF571 or be part of the transcriptional machinery that ZNF571 controls, potentially enhancing its functional activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for many zinc finger proteins, including ZNF571. Zinc sulfate can provide zinc ions, which are essential for the structural integrity and DNA-binding activity of ZNF571, therefore directly enhancing its functional role as a transcription factor. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can raise endosomal pH and has been shown to affect intracellular signaling pathways. By altering endosomal signaling, it may lead to activation of transcription factors or cofactors required for ZNF571 functional activation or enhance its DNA binding capability. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is known to influence multiple signaling pathways and has been shown to modulate kinase activity. This modulation could enhance the phosphorylation state of proteins that interact with ZNF571 or alter coactivator availability, thus promoting ZNF571 activation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is a polyamine that can influence cellular processes and signaling pathways involved in cell growth and differentiation. By modulating these pathways, spermidine may enhance the functional activity of ZNF571, especially in contexts where ZNF571 is involved in the regulation of these processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects various signaling pathways, including those involving transcription factors and kinases. It may enhance ZNF571 activity by influencing the phosphorylation state or the availability of cofactors that ZNF571 requires for its functional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol interacts with multiple signaling pathways, including sirtuins and AMPK, which can influence the activity of various transcription factors. Through these pathways, resveratrol might promote the activation of ZNF571 or enhance its interaction with other proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can affect chromatin structure and gene expression. By altering the chromatin landscape, it may facilitate access for ZNF571 to its target DNA sequences, thereby promoting its functional activation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, through its active metabolite calcitriol, engages the vitamin D receptor (VDR), which interacts with many transcription factors. This interaction may promote the activation of ZNF571 by enhancing its DNA-binding ability or interaction with other transcriptional machinery components. | ||||||