ZNF496 Inhibitors
ZNF496 inhibitors encompass a range of chemical compounds that interfere with various cellular signaling pathways and processes, ultimately leading to the inhibition of ZNF496 activity. Rapamycin, through the inhibition of the mTORC1 complex, impacts the mTOR signaling pathway that is associated with ZNF496, diminishing the protein's activity in cellular growth and metabolism. Trichostatin A and 5-Azacytidine, inhibitors of HDAC and DNA methyltransferase respectively, alter the epigenetic landscape, potentially reducing ZNF496's DNA-binding capacity and its regulatory effect on gene expression. The proteasome inhibitors MG-132 and Bortezomib disrupt protein turnover and induce stress responses, which could indirectly inhibit ZNF496's regulatory stability and capacity. LY 294002 and PD 98059 target the PI3K and MEK enzymes respectively, thereby potentially disturbing ZNF496's activity within cell growth and survival pathways, as well as MAPK-dependent signaling processes.
Moreover, compounds such as SB 431542, a TGF-β receptor inhibitor, and Cyclopamine, a Hedgehog pathway inhibitor, could indirectly diminish ZNF496's functional role by altering the transcriptional programs within cells. GW4869, by inhibiting neutral sphingomyelinase, affects lipid signaling pathways and could thus impact ZNF496's role in cellular signaling. Y-27632, a ROCK inhibitor, could lead to decreased ZNF496 activity by altering cellular architecture and cytoskeletal organization. Lastly, JQ1, as a BET bromodomain inhibitor, disrupts the reading of acetylated histones, which could inhibit the transcriptional influence of ZNF496 by disrupting the gene regulatory network it is involved in. Collectively, these inhibitors utilize diverse biochemical mechanisms to attenuate the functional activity of ZNF496, each affecting a distinct facet of the cellular environment and signaling pathways that ZNF496 is poised to regulate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that reduces the activity of the mTORC1 complex. ZNF496 has been linked to the mTOR signaling pathway; thus, inhibition of mTORC1 by rapamycin could potentially diminish the functional activity of ZNF496 due to the downstream effects on the cellular growth and metabolic regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. HDAC inhibition results in hyperacetylation of histones, affecting gene expression. As ZNF496 is a transcription factor, alteration in the chromatin structure may indirectly inhibit the DNA-binding ability of ZNF496, reducing its regulatory impact on gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, leading to hypomethylation of DNA. This can alter gene expression patterns, potentially disrupting the regulatory network in which ZNF496 operates, thereby diminishing its functional activity by altering the expression of genes that ZNF496 might regulate. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that could lead to the accumulation of misfolded or ubiquitinated proteins, inducing cellular stress. This can interfere with the normal function of ZNF496 by potentially altering its post-translational modification state or by inducing a general stress response that diminishes ZNF496 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a PI3K inhibitor, and PI3K signaling is crucial for various cellular processes. By inhibiting PI3K, LY 294002 can indirectly affect the function of ZNF496 by disturbing the cellular context in which ZNF496 operates, particularly in pathways related to cell growth and survival where ZNF496 might play a role. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 is an inhibitor of the TGF-β receptor. TGF-β signaling affects a wide array of cellular functions, including differentiation and proliferation. Inhibition of this pathway can indirectly affect ZNF496 function by altering the transcriptional programs within cells that ZNF496 may regulate. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an MEK inhibitor which acts upstream of ERK in the MAPK pathway. By inhibiting MEK, PD 98059 can indirectly diminish the functional activity of ZNF496 if ZNF496 activity is modulated through MAPK-dependent signaling pathways, which play a role in cell proliferation and differentiation. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a Hedgehog pathway inhibitor, specifically targeting Smoothened. Since ZNF496 could be involved in regulatory networks modulated by the Hedgehog signaling pathway, the inhibition of this pathway by cyclopamine could diminish ZNF496's functional role in these processes. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is an inhibitor of neutral sphingomyelinase, which is involved in ceramide biosynthesis, a component of lipid signaling pathways. By inhibiting this enzyme, GW4869 could affect the lipid environment and signaling pathways, potentially diminishing the functional activity of ZNF496 in cellular signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which impacts cytoskeleton dynamics and cellular contractility. Since ZNF496 might affect gene expression related to cytoskeletal organization, the inhibition of ROCK signaling by Y-27632 could indirectly lead to decreased functional activity of ZNF496 by altering the cellular architecture. | ||||||