ZNF470 Inhibitors
Chemical inhibitors of ZNF470 can disrupt the protein's function through various molecular pathways. Triptolide and MG132, for instance, exert their inhibitory action by targeting the NF-κB pathway, which is crucial for the transcriptional regulation that ZNF470 is involved in. Triptolide does this by directly inhibiting the transcription factor NF-κB itself, while MG132 impedes the proteasomal degradation of IκB, the inhibitor of NF-κB. This results in the suppression of NF-κB's transcriptional activity, which can impact the regulatory roles of ZNF470 if it is involved in the NF-κB pathway. Similarly, IKK-16 also targets the NF-κB pathway but does so by inhibiting IκB kinase, thereby preventing the activation of NF-κB and possibly affecting ZNF470's function in transcriptional regulation.
Other inhibitors disrupt pathways that could intersect with ZNF470's role in transcriptional regulation. LY294002 and Wortmannin both inhibit PI3K, a key component of the signaling pathways that regulate numerous cellular functions, including transcription. The inhibition of PI3K can decrease transcriptional activities that ZNF470 regulates. Apigenin impedes the activity of protein kinase C, which can modulate the activity of various transcription factors, potentially altering ZNF470's interaction with other proteins in transcriptional regulation. U0126 and PD98059 are both MEK inhibitors and would inhibit the MEK/ERK signaling that may be necessary for ZNF470's regulatory functions. Inhibition of this pathway can impair the activities of transcription factors or cofactors that work in concert with ZNF470. SB203580 and SP600125 target the p38 MAPK and JNK pathways, respectively, both of which are involved in regulating transcription factors and their cofactors. By inhibiting these kinases, the chemical inhibitors can disrupt the regulatory processes in which ZNF470 is known to function. Lastly, rapamycin inhibits mTOR, which can impact the translation of proteins essential for transcriptional regulation, potentially affecting ZNF470 if it interacts with such proteins.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is a diterpene triepoxide that inhibits the transcription factor NF-κB. Since ZNF470 is a zinc finger protein involved in transcriptional regulation, inhibition of NF-κB could disrupt transcriptional activities that ZNF470 may be a part of, leading to its functional inhibition. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin. By inhibiting calcineurin, it could prevent the dephosphorylation and nuclear translocation of NFAT, a transcription factor. If ZNF470 functions in a pathway with NFAT, inhibiting NFAT could result in functional inhibition of ZNF470 by preventing its association with transcriptional complexes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of inhibitor kappa B (IκB), resulting in the inhibition of NF-κB. ZNF470, being a transcriptional regulator, could be functionally inhibited if NF-κB, a pathway component it interacts with, is inhibited, since this would disrupt transcriptional regulation processes where ZNF470 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. PI3K is part of signaling pathways that regulate various cellular processes including transcription. Inhibition of PI3K could lead to a decrease in transcriptional activities regulated by ZNF470, thereby functionally inhibiting its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK). Inhibition of MEK/ERK signaling could impair the activities of transcription factors and cofactors interacting with ZNF470, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. The p38 MAPK pathway is involved in the regulation of transcription factors and their cofactors. Inhibition of p38 MAPK could disrupt transcriptional regulation processes where ZNF470 is known to function, leading to functional inhibition of ZNF470. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which impacts transcription factor activity. If ZNF470's function is linked to JNK-regulated transcription factors, then inhibition of JNK could lead to functional inhibition of ZNF470. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K, similar to LY294002, and would functionally inhibit ZNF470 by the same mechanism, through the disruption of PI3K dependent signaling pathways that regulate transcriptional processes involving ZNF470. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $219.00 $924.00 | 2 | |
IKK-16 is an inhibitor of IκB kinase (IKK), which is responsible for the phosphorylation and degradation of IκB, an inhibitor of NF-κB. Inhibition of IKK would prevent NF-κB activation, potentially leading to functional inhibition of ZNF470 if it is involved in transcriptional regulation with NF-κB. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavone that has been shown to inhibit protein kinase C (PKC). Since PKC can modulate the activity of various transcription factors and ZNF470 is a transcriptional regulator, inhibition of PKC could functionally inhibit ZNF470 by altering its interactions with other proteins in transcriptional regulation. | ||||||