ZNF41 Inhibitors
ZNF41 inhibitors encompass a range of compounds that exert their inhibitory effects through various biochemical mechanisms, indirectly leading to decreased functional activity of ZNF41. These inhibitors target pathways that ZNF41 is likely to interact with due to its role in DNA binding and transcriptional regulation. The activity of protein kinases, which ZNF41 may rely on for signal transduction relating to gene expression, is dampened by certain inhibitors, thereby potentially impacting ZNF41's regulatory functions. Similarly, proteasome inhibitors stabilize proteins that are marked for degradation, which could affect the normal turnover of ZNF41, thereby influencing its activity. Inhibitors that interfere with histone acetylation and DNA methylation also play a role, as they alter the chromatin structure and, as a result, affect how ZNF41 interacts with the genome. By shifting the epigenetic environment, these inhibitors can either prevent ZNF41 from accessing its target genes or alter the transcriptional machinery's response to ZNF41 binding. This modulation of epigenetic markers is a key strategy in affecting the function of ZNF41, as it dictates the protein's ability to influence gene expression profiles without necessitating a direct blockade of the protein itself.
Additionally, compounds that block the physical interaction between ZNF41 and its co-regulatory proteins could disrupt the formation of transcriptional complexes essential for ZNF41's gene-regulating activities. Small molecule inhibitors that mimic or bind to the zinc finger motifs of ZNF41 could prevent it from interacting with DNA, thereby impeding its ability to act as a transcription factor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor known to block the activity of protein kinases. ZNF41, being a zinc finger protein, may interact with kinase signaling pathways for its DNA binding and transcriptional regulation functions. Inhibition of these kinases may impact ZNF41's activity indirectly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can prevent the degradation of proteins, potentially including ZNF41. By impairing the proteasomal degradation pathway, levels of ZNF41 that are marked for degradation could be stabilized, affecting its normal regulatory turnover and activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that impedes the PI3K/Akt signaling pathway. Since zinc finger proteins like ZNF41 can be involved in signal transduction, blocking this pathway may indirectly reduce ZNF41's regulatory effects on gene expression and DNA interaction. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that changes chromatin structure and gene expression. ZNF41's function in transcriptional regulation could be altered as a result, due to the modifications in the chromatin landscape where ZNF41 would typically bind and act. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that leads to hypomethylation of DNA. ZNF41's DNA binding and gene regulation might be affected by changes in DNA methylation status, as these could alter the binding sites and interaction dynamics of ZNF41 with the genome. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
An MDM2 antagonist that stabilizes p53, potentially affecting the p53 pathway. ZNF41 might interact with p53-regulated genes, and thus stabilizing p53 could indirectly limit ZNF41's ability to regulate certain genes or be recruited to specific DNA regions. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase inhibitor that can arrest cell cycle progression. By disrupting cell cycle regulation, ZNF41's role in the cell cycle, if any, would be indirectly inhibited due to changes in the cellular environment and transcriptional demands. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK, which subsequently blocks the ERK/MAPK pathway. Since ZNF41 could be modulating gene expression in response to signals from this pathway, inhibiting ERK/MAPK signaling could alter ZNF41's transcriptional activity. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
A modulator of the ubiquitin-proteasome system, affecting the degradation of proteins. As ZNF41 protein levels might be regulated via ubiquitination, thalidomide could influence its stability and function in the cell. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that affects cellular growth and metabolism. ZNF41, as a transcriptional regulator, could be implicated in pathways modulated by mTOR, and therefore rapamycin might indirectly inhibit the functional activity of ZNF41. | ||||||