ZNF313 Activators
ZNF313, also known as RNF114, is a zinc finger protein that has garnered attention for its role in the regulation of immune responses and cellular stress pathways. As a member of the E3 ubiquitin-protein ligase family, ZNF313 plays a crucial role in the ubiquitination process, a post-translational modification that tags specific proteins for degradation by the proteasome. This activity is fundamental in maintaining cellular homeostasis, regulating protein turnover, and modulating signaling pathways critical for cell survival, proliferation, and differentiation. The precise function of ZNF313 extends to the regulation of NF-κB signaling, a central pathway in immune response and inflammation, suggesting that ZNF313's activation could influence immune cell function and inflammatory responses. By modulating the degradation of key signaling molecules, ZNF313 influences the threshold for cellular responses to external stimuli, highlighting its importance in both innate and adaptive immunity.
The activation of ZNF313 involves complex regulatory mechanisms that ensure its activity is precisely controlled in response to specific cellular cues. One potential mechanism of ZNF313 activation is through post-translational modifications, such as phosphorylation or sumoylation, which could alter its conformation, stability, or interaction with substrates and cofactors. The activation could also be regulated through interactions with specific signaling molecules or changes in intracellular localization in response to stress signals or immune triggers. For example, the activation of stress-responsive pathways, such as the unfolded protein response (UPR) or the heat shock response, may upregulate ZNF313 expression or activity, enabling the cell to adapt to and survive adverse conditions. Similarly, signaling molecules involved in the immune response could enhance ZNF313 activity, leading to the targeted degradation of inhibitors of NF-κB, thus promoting the transcription of genes involved in inflammation and defense mechanisms. Through these pathways, ZNF313 acts as a critical modulator of cellular responses to environmental changes, underscoring the intricate web of regulatory mechanisms that control its activation and function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione is a coordination complex of zinc. ZNF313, as a zinc finger protein, requires zinc ions for its structural stability and function. The presence of zinc pyrithione can potentially enhance the binding affinity of zinc to ZNF313, thereby potentially enhancing its activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine is a biogenic amine that can activate G-protein coupled receptors (GPCRs). This activation can lead to intracellular signaling cascades that involve gene expression regulation, potentially increasing the expression and functional activity of ZNF313. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can phosphorylate transcription factors and other regulatory proteins, potentially enhancing the regulatory functions of ZNF313. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This can activate calcium-dependent signaling pathways, possibly influencing the activity of ZNF313 as it may interact with other proteins regulated by calcium signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator that can modulate transcription factors and other signaling proteins. PKC activation might enhance the functional activity of ZNF313 by altering the phosphorylation state of proteins that interact with or regulate ZNF313. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A that regulates gene expression. It can influence the transcriptional activity of ZNF313 by binding to retinoic acid receptors, which may interact with ZNF313 or modulate genes that are targets of ZNF313. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit multiple kinases. By inhibiting competitive signaling pathways, EGCG may enhance the signaling pathways that ZNF313 is involved in, potentially increasing ZNF313's activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is an HDAC inhibitor that can lead to hyperacetylation of histones, enhancing transcription of certain genes. This could increase the expression of ZNF313, providing an indirect enhancement of its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, this compound may shift the balance of intracellular signaling pathways, potentially resulting in the activation of alternative pathways that enhance the function of ZNF313. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, broad-spectrum protein kinase inhibitor. Although it generally inhibits kinase activity, it may lead to the selective activation of pathways involving ZNF313 by inhibiting kinases that negatively regulate pathways ZNF313 is involved in. | ||||||