ZNF28 Activators
ZNF28 engage diverse cellular pathways to facilitate its activation. Phorbol 12-myristate 13-acetate (PMA), by activating protein kinase C (PKC), initiates a cascade of phosphorylation events. This modification of proteins within the cell can lead to the activation of ZNF28 as PKC can enhance the DNA binding affinity of transcription factors. Similarly, forskolin, by elevating cAMP levels, activates protein kinase A (PKA), which then can also phosphorylate and activate ZNF28. Ionomycin, through its action as a calcium ionophore, raises intracellular calcium levels, which, in turn, can activate calmodulin-dependent protein kinases. These kinases have the capacity to phosphorylate transcription factors, thereby potentially facilitating the activation of ZNF28.
The impact of growth factors and hormones on ZNF28 activation is also notable. Epidermal Growth Factor (EGF) triggers its receptor, setting off a signaling cascade that includes the MAPK/ERK pathway, known to phosphorylate transcription factors which can result in the activation of ZNF28. Insulin, by activating its receptor, initiates signaling pathways like PI3K/Akt and can lead to the phosphorylation of transcription factors, including ZNF28. Retinoic Acid and Vitamin D3, through their respective nuclear receptors, alter gene expression that can result in ZNF28 activation. Dibutyryl-cAMP, a permeable analog of cAMP, directly activates PKA, which can lead to ZNF28 activation. Zinc, essential for the structural integrity of zinc finger domains in DNA-binding proteins, can stabilize and thereby activate ZNF28. Hydrogen Peroxide serves as a signaling molecule that can alter the activity of phosphatases and kinases, leading to ZNF28 activation. Lastly, histone deacetylase inhibitors like Sodium Butyrate and Trichostatin A modify chromatin structure, which enhances the accessibility of transcription factors to DNA, facilitating the activation of ZNF28.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol esters like PMA are known to activate protein kinase C (PKC), which can lead to the phosphorylation and activation of various proteins, including transcription factors like ZNF28, by enhancing their DNA binding affinity and functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which in turn activates PKA. PKA can phosphorylate various proteins, potentially including ZNF28, thus promoting its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased calcium can activate calmodulin-dependent protein kinases, which may phosphorylate and activate ZNF28 as part of signaling cascades. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation triggers signaling pathways such as PI3K/Akt, leading to the activation of downstream effector proteins. This signaling cascade can phosphorylate and activate transcription factors, potentially including ZNF28. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to its nuclear receptors which can heterodimerize with other nuclear receptors. This complex can interact with and modulate transcription factors, potentially leading to the activation of ZNF28 through altered gene expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 through its active form calcitriol binds to the vitamin D receptor (VDR), and the VDR-retinoid X receptor complex can influence transcription factor activity, possibly leading to the activation of ZNF28. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that permeates cell membranes and activates PKA. Activated PKA can phosphorylate multiple proteins, potentially leading to the activation of ZNF28 through phosphorylation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can act as a cofactor for many DNA-binding proteins with zinc finger motifs, such as ZNF28, potentially leading to the structural stabilization and activation of their DNA-binding capacity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can act as a signaling molecule that modulates the activity of phosphatases and kinases, potentially leading to the activation of transcription factors like ZNF28 through oxidative signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can lead to the hyperacetylation of histones, affecting chromatin structure and gene expression. This can enhance the accessibility of DNA to transcription factors, including ZNF28. | ||||||