ZNF223 Inhibitors
Chemical inhibitors of ZNF223 include a diverse array of compounds that interfere with cellular pathways, leading to the inhibition of ZNF223 activity. Trichostatin A, for instance, operates as a histone deacetylase inhibitor which results in the hyperacetylation of histones. This alteration in the chromatin structure can inhibit the DNA binding capability of ZNF223, thereby obstructing its function. In a similar vein, MG132 acts as a proteasome inhibitor, preventing the degradation of ubiquitinated proteins. This accumulation can lead to the inhibition of ZNF223 through competitive or allosteric interactions by regulatory proteins. LY294002, a PI3K inhibitor, and Wortmannin exert their effects by diminishing AKT phosphorylation, which is crucial for the activity of proteins that ZNF223 interacts with, thus leading to its inhibition. Furthermore, PD98059 and U0126, both of which are MEK inhibitors, block the MAPK/ERK pathway that is vital for the phosphorylation and subsequent activity of proteins that regulate ZNF223.
Continuing on this mechanistic journey, SB203580, a p38 MAP kinase inhibitor, and Rapamycin, an mTOR inhibitor, disrupt the phosphorylation states and downstream signaling of pathways crucial for ZNF223's regulatory proteins, culminating in the inhibition of ZNF223. Tyrosine kinase inhibitors such as Sunitinib and Lapatinib interfere with signaling pathways by blocking receptor tyrosine kinases that could be essential for the functional activity of ZNF223, leading to its inhibition. Lastly, cyclin-dependent kinase inhibitors like Alsterpaullone and Palbociclib inhibit CDKs, which are integral to the phosphorylation process of proteins that interact with ZNF223. By halting this phosphorylation, these inhibitors contribute to the suppression of ZNF223 activity, effectively inhibiting the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor can lead to the hyperacetylation of histones, causing a change in chromatin structure and potentially inhibiting the DNA binding ability of ZNF223, leading to functional inhibition. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor which can prevent the degradation of ubiquitinated proteins, potentially leading to the accumulation of regulatory proteins that may inhibit the function of ZNF223 by competitive or allosteric interactions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can reduce AKT phosphorylation, which may be critical for the phosphorylation state and function of proteins that interact with ZNF223, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway, potentially inhibiting the phosphorylation of proteins that interact with or regulate ZNF223, leading to functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase, potentially altering the phosphorylation state of proteins that interact with ZNF223, resulting in functional inhibition of ZNF223. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which can disrupt downstream signaling, possibly leading to the deactivation of regulatory proteins that are involved in the functional activity of ZNF223, causing inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
This PI3K inhibitor can also impact AKT signaling, possibly preventing the phosphorylation of proteins that are necessary for the functional activity of ZNF223, leading to its inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
By inhibiting MEK, this compound can block the ERK pathway, potentially leading to the inhibition of proteins that regulate or interact with ZNF223, resulting in functional inhibition. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
A receptor tyrosine kinase inhibitor, which by inhibiting these kinases, may inhibit signaling required for the functional activity of ZNF223, leading to its inhibition. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
This inhibitor of EGFR and HER2/neu tyrosine kinases can inhibit signaling pathways that may be necessary for the functional activity of ZNF223, leading to its inhibition. | ||||||