ZNF216 Inhibitors

Proteasome inhibitors such as MG132, Bortezomib, Lactacystin, Epoxomicin, and PS-341. These compounds can increase the levels of proteins within the cell by preventing their degradation. By inhibiting the proteasome complex, these chemicals can indirectly influence the stability and functional levels of ZNF216, which, like many proteins, may be subject to regulated degradation by the ubiquitin-proteasome system.

Similarly, compounds targeting the PI3K/Akt/mTOR pathway, including PIK-75, LY294002, Rapamycin, and Wortmannin, can modulate protein synthesis and cellular growth signals, pathways that ZNF216 could intersect with. These chemicals can alter the cellular environment in a manner that may impact ZNF216's activity, stability, or interaction with other proteins. Lastly, modulators of gene expression such as Trichostatin A and Suberoylanilide Hydroxamic Acid, through their inhibition of histone deacetylases, and SB431542, through its inhibition of TGF-β signaling, can influence transcriptional and post-transcriptional regulation processes. Such changes in gene expression and cellular signaling could alter the functional context in which ZNF216 operates, thereby indirectly affecting its activity.