ZNF195 Inhibitors
Chemical inhibitors of ZNF195 can be categorized based on the signaling pathways they target. Staurosporine, a potent nonspecific protein kinase inhibitor, can inhibit a vast array of kinases, which in turn can reduce the phosphorylation of proteins including ZNF195 if such phosphorylation is necessary for its activity. Bisindolylmaleimide I, which is more selective, targets protein kinase C (PKC). As PKC is a pivotal player in numerous cellular processes, its inhibition by Bisindolylmaleimide I can decrease the phosphorylation of ZNF195 if PKC is involved in its activation. Similarly, LY294002 and Wortmannin are both inhibitors of phosphoinositide 3-kinases (PI3K), and their action can lead to decreased activation of downstream targets that may include kinases responsible for the phosphorylation of ZNF195.
In the context of the MAPK pathway, several inhibitors can affect the activity of ZNF195. PD98059 and U0126 are selective inhibitors of MEK, an upstream kinase in the MAPK/ERK pathway. By preventing MEK activity, these inhibitors can reduce the downstream ERK activity, which can subsequently lead to reduced phosphorylation and activation of ZNF195 if it is part of the ERK pathway. SB203580, which specifically inhibits p38 MAP kinase, and SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), function similarly by targeting specific kinases within the MAPK pathway and can diminish the phosphorylation of downstream proteins, potentially including ZNF195. Rapamycin, an mTOR inhibitor, can suppress the mTOR signaling cascade, potentially affecting proteins regulated by this pathway that may be involved in ZNF195 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor known to inhibit a wide range of kinases. ZNF195 activity could be inhibited by staurosporine through the inhibition of kinases that are responsible for the phosphorylation that activates ZNF195. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). As PKC is involved in a multitude of signaling pathways, the inhibition of PKC could lead to a reduction in the phosphorylation and thereby the activity of ZNF195, presuming that ZNF195 is regulated by PKC-dependent phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). Inhibition of PI3K could decrease activation of downstream proteins that might regulate the activity of ZNF195, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is involved in the MAPK/ERK pathway. Inhibition of MEK could reduce the activity of ERK, which in turn could inhibit the phosphorylation and activation of ZNF195. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and by inhibiting mTOR activity, it could lead to the inhibition of downstream effectors that regulate the activity of ZNF195. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of MAPK/ERK pathway. By inhibiting MEK, the phosphorylation and subsequent activity of proteins in the pathway, potentially including ZNF195, would be inhibited. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, part of the MAPK pathway. Inhibition of p38 MAP kinase could lead to the inhibition of downstream signaling processes that might control the phosphorylation and function of ZNF195. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it could inhibit the activation of proteins downstream in the pathway that might regulate ZNF195 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK pathway. Inhibition of JNK could lead to the inhibition of proteins downstream, potentially influencing the activity of ZNF195. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib inhibits multiple receptor tyrosine kinases. The inhibition of these kinases could lead to the inhibition of signaling pathways that regulate the phosphorylation and activity of ZNF195. | ||||||